Tissue Compostition

Question 1

What are the four primary tissue components?

Answer 1

collage
Elastic
Ground substance
water

Question 2

How many different types of collagen?

Answer 2

15

Question 3

This tissue has continuous metabolic turnover through growth to maturity.

Answer 3

collagen

Question 4

When do the collagen fibers become more stable?

Answer 4

At maturity

Question 5

Collagen molecules are secreted and synthesized by what?

Answer 5

fibroblasts

Question 6

Collagen molecules align in what fashion and where?

Answer 6

Parallel,

In the extracellular matrix

Question 7

How far can collage stretch without breaking?

Answer 7

110% of original length

Question 8

How does collagen change under tension?

Answer 8

Increase ligament strength and size.

Question 9

How does collagen increase in ligament size during tension?

Answer 9

Increase in 
# of collagen fibrils, 
fibril diameter, 
cross-linking, 
fibril packing density.

Question 10

What things decrease with degenerative ligament changes? (5 things)

Answer 10

Diameter
Density
Number
Mass
metabolism

Question 11

During immobilization, what happens at the ligament-bone junction?

Answer 11

• Increase osteoclast activity
• bone restoration
• Disruption of pattern of diffusion of ligament fibers into the bone

Question 12

Elastic can stretch _____% of original length without breaking.

Answer 12

150

Question 13

What happens to elastic with age?

Answer 13

Lost resiliency
Fragmentation and fraying
Calcification
Increased # of cross-links

Question 14

Ground substance aka

Answer 14

Cementing substance

Question 15

What is amorphous gel like substance surrounding the cells?

Answer 15

Ground substance

Question 16

Water is ______% of the total connective tissue content.

Answer 16

60-70%

Question 17

What is the protein or peptide which the GAGs are covalently attached to?

Answer 17

proteoglycan

Question 18

What are the four major GAGs?

Answer 18

Hyaluronic acid
Chondroitin-4-sulfate
chondroitin-6-sulfate
dermatan sulfate

Question 19

What is it when water moves to areas of high salute concentration?

Answer 19

osmosis

Question 20

What is a powerful lubricant?

Answer 20

Water + hyaluronic acid

Question 21

Water maintains what between collagen fibers?

Answer 21

CRITICAL DISTANCE

Question 22

What two things does water do?

Answer 22

Allows free gliding

Prevents excessive cross-linking