Tissue Architecture Flashcards
Great tensile strength (rope); found in cytoplasm of most cells; anchored to membrane at cell-cell junctions; and form mesh nuclear lamina to strengthen the nuclear envelop
Intermediate Filaments
organization in all eukaryotic cells; long, stiff tubes; rapidly assemble and disassemble; extend from centrosome to periphery (tracks for vesicles); form mitotic spindle; and part of flagella and cilia
Microtubules
Microtubule arrangement
alpha and beta heterodimers; often growing from a gamma tubulin
Actin filaments (F actin); present in all cell types; many unstable but key for cell movements
Microfilaments
Phalloidin, Cytochalasin, and Latrunculin
Drugs affecting actin filaments (microfilaments)
components produced inside cells and secreted; matrix that interacts with cells and tissues via transmembrane proteins; composition and properties controlled and vary by tissue type
Extracellular matrix and basal lamina
Main structural protein in ECM; trimeric (homo or hetero) forms collagenous triple helix; associate as fibers, sheets, or transmembrane structures
Collagen
Anchoring Junctions
junctions from cell-cell, cell-BL, or cell-ECM; cells connected also to cytoskeletal filaments
Occluding Junctions
help maintain cell polarity by preventing movement of things between or out of cells
Gap/channel forming junctions
allow for movement of cellular components between cells
Signal relaying junctions
synapse; neuronal junctions
EMT and Cadherin Switching
Cadherin servers as biomarker for invasive, metastatic tumors; in transition, epithelial cadherin turns more towards N cadherin
Ca2+ dependent; key for adhesion between cells (epithelial sheets; desmosomes); homophilic interactions and interacts with actin cytoskeleton
Cadherin Superfamily
Cadherin types
E, N, VE, and LI
calcium independent glycoproteins; key in immune cell interactions; expressed on vascular-endothelial cells and bind to integrin; homophilic or heterophilic binding
Ig Superfamily
