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MCM > Inhibitors > Flashcards

Inhibitors Flashcards

1
Q

Binds to the 30s subunit interfering with binding fMet-tRNA; prevents initiation by stopping association with 50s

A

Streptomycin

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2
Q

binds to 30s preventing aminoacyl-tRNA from entering complex

A

Tetracycline

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3
Q

Inhibits peptidyl transferase (elongation) in prokaryotes and mitochondria

A

Chloramphenicol

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4
Q

Binds to 50s, blocking translocation of ribosome

A

Clindamycin and Erythromycin (pertussis)

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5
Q

Inhibits peptidyl transferase in eukaryotes; Strep. griesua

A

Cycloheximide

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6
Q

inactivates GTP bound EF-2; interfering with eukaryotic ribosomal translocation

A

Diptheria Toxin

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7
Q

Bind to 60s of eukaryotes and prevent the entry of aminoacyl-tRNA to complex

A

Shiga Toxin and Ricin

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8
Q

Premature chain termination in prokaryotes and eukaryotes; elongation inhibitor

A

Puromycin

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9
Q

Block DNA replication; affect all phases of cell cycle

A

Alkylating agents

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10
Q

Inhibit topoisomerase II, which gets rid of tangles in DNA

A

Topoisomerase II inhibitors in S phase (Etoposide)

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11
Q

Inhibit enzymes involved with DNA synthesis

A

Antimetabolites

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12
Q

Intercalate between bases in DNA to inhibit synthesis

A

Cytotoxic antibiotics

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13
Q

Inhibit topoisomerase I, which removes supercoils in DNA

A

Topoisomerase I inhibitors in G2 (Irinotecan)

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14
Q

Arrest cells in mitosis during metaphase

A

Mitotic inhibitors

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15
Q

Binds and stabilizes microtubules

A

Taxol

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16
Q

Colchicine (colcemid) and Vinblastine (Vincristine)

A

Binds tubulin dimers and prevents polymerization

17
Q

Binds and stabilizes actin (micro) filaments preventing their depolymerization

A

phalloidin

18
Q

Cytochalasin

A

caps filament plus ends; preventing further polymerization

19
Q

Latrunculin

A

Binds actin monomers to prevent polymerization

MCM (16 decks)

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