tissue A&P Flashcards
histology
study of plant/animal tissue
how many types of cells
200 types
trillions of cells
tissue is a group of ____ with similar ____ and shared ____
group of cells with similar origin and shared function
4 main tissue types
nervous
muscle
epithelial
connective
origin of tissue types
from GERM LAYERS
during EMBRYONIC DEVELOPMENT
3 germ layers
ectoderm (outer)
mesoderm (middle)
endoderm (iner)
ectoderm becomes
nervous system
integumentary system
mesoderm becomes
bone
muscle
connective tissue (includes bone)
some organs (including kidneys and reproductive organs)
endoderm becomes
lining of digestive system
lining of respiratory system
urethra
some organs (including liver/pancreas/bladder)
Cell junctions (5 types)
tight junctions (occluding “)
adherens junctions (adhesion belts)
desmosomes
hemidesmosomes
gap junctions
cell junctions function
join cells to form tissue
4 specific functions of cell junctions
1) link cells in tissues
2) tissue homeostasis
3) tissue barrier
4) cell proliferation (division)
1) Tight Junctions
transmembrane proteins
interlock plasma membranes
NO WATER PASS (leak-proof)
separate BASOLATERAL (cell?) surfaces from LUMEN
where are tight junctions
STOMACH
BLADDER
INTESTINAL TRACT (isolate basolateral from lumen)
(Leak proof)
2) Adherens junctions (Adhesion belts)
contain protein called PLAQUE (Actin filaments)
microfilaments (Actin) form “Plaque”
=== THE BELT
BELTS then connected via CADHERIN
= transmembrane GLYCOprotein
“plaque” (adherens junctions)
made of ACTIN filaments
INSIDE of cell membrane
Cadherin is transmembrane ____-protein
glycoprotein
cadherin attach to adjacent ____
cadherins
each connected to ACTIN filaments of PLAQUE (adhesion belt)
function of adherens junctions (adhesion belts)
prevent separation of EPITHELIAL surfaces
esp during contractile activities
e.g. peristalsis
why “belts” ?
encircle cell
3) desmosomes
also via PLAQUE
supported via INTERMEDIATE FILAMENTS
Intermediate filaments via KERATIN
like “buttons” at specific spots
also via CADHERINS
intermediate filaments via
KERATIN
where are desmosomes found
epidermis
cardiac muscle cells
4) Hemidesmosomes
cell to BASEMENT MEMBRANE
structure similar to desmosome
via INTEGRIN (instead of Cadherin)
Integrins attach to laminins
INTEGRIN = ____-protein
glyco-protein
transmembrane
integrin attaches to external proteins called ____
Laminins
(BASAL LAMINA)
where are hemidesmosomes found?
between the epidermis and dermis
basement membrane
epithelial cells grow on “
attaches epithelial to connective
5) Gap junctions
via CONNEXONS
connexons via CONNEXINS
intercellular transport
e.g.
ions, nutrients, waste
connexons form HYDROPHILIC channel (?)
(GAP JUNCTIONS) connexons and electric signals
conduction of electric signals
(I.e. Movement of ions)
gap junctions and heart
electrical signal spreads via gap junctions
heart muscles contract – heart beat
epithelial tissue
lines internal and external surfaces
forms secretion glands
cells arranged in layers
single or multiple layers
+ NERVE SUPPLY
- BLOOD SUPPLY (less)
epithelium function
1) PROTECT (chemical/physical)
2) ABSORB (nutrient)
3) SECRETE (hormones/enzymes)
4) EXCRETE (waste)
cell polarity & Epithelial cells
“Spatial differences in shape/structure/function”
“Epithelial cells have polarity, meaning they have distinct cell surfaces”
Superficial surface different from deep surface and from sides of cell
3 Cell surfaces
APICAL
LATERAL
BASAL
1) Apical surface
opens into body cavity/lumen
may contain cilia/microvilli
E.g.
Stomach – surface of cells that interact with food (CHYME)
2) Lateral surface
adjacent cells
cell-to-cell junctions (4)
4:
tight
adherens
desmosome
gap
3) Basal surface
opposite to apical
attach to basement membrane + Connective tissue underneath
basement membrane.
attaches epithelial to connective tissue
2 layers:
1) BASAL lamina
2) RETICULAR lamina
1) basal lamina
Collagen fibres
LAMININ (glycoprotein)
other glycoproteins
proteoglycans (note GAG)
2) reticular lamina
fibrous proteins (stronger)
via Fibroblasts
epithelium classification
1) Number of cell layers
2) Shape of individual cells
1) number of cell layers
simple epithelium
stratified
pseudostratified (ciliated or non-ciliated)
where simple epithelium?
capillaries
alveolar sacs (lungs)
why simple epithelium?
fast exchange across epithelium
where stratified?
inside mouth
pharynx
esophagus
why stratified?
strength/reinforcement
protection
when cell layer shed (“slough”)
e.g.
skin (epidermis)
where pseudostratified?
can be ciliated or non-ciliated
ciliated
= respiratory tract (mucosa)
non-ciliated
= male reproductive tract
2) shape of individual cells
squamous
cuboidal
columnar
transitional
*Squamous
flat
high rate of absorption
E.g.
Capillaries
Alveolar sacs of lungs
**Cuboidal
cube shaped
may have microvilli
Secretion and Absorption
***Columnar
may have microvilli
secretion/absorption
E.g.
Stomach
small intestine lining
**Transitional
can alter between cuboidal and squamous
“distension and stretch”
E.g.
Bladder
Ureters
Urethra (some parts)
combinations of
1) # of cell layers
and
2) shape of individual cell
Simple squamous
simple cuboidal
non-ciliated simple columnar
ciliated simple columnar
non-ciliated pseudostratified columnar
ciliated pseudostratified columnar
stratified squamous
stratified cuboidal
stratified columnar
transitional
goblet cells
simple squamous epithelium
inside of blood vessels
(ENDOTHELIUM)
inside of heart
(ENDOCARDIUM)
air sacs (alveoli) of lungs
epithelial layer of serous membranes
(MESOTHELIUM)
I.e.
of Peritoneal, Thoracic, Pericardial cavities
(PERITONEUM,
PLEURA,
PERICARDIUM)
simple squamous epithelium …
endothelium
endocardium
mesothelium
simple cuboidal epithelium
round centrally located nucleus
secretion/absorption
E.g.
surface of ovary
anterior surface of lens capsule of eye
pigmented epithelium of retina of eye
KIDNEY TUBULES
secreting portion of glands
e.g.
THYROID GLAND
non-ciliated simple columnar
see GOBLET CELLS
note also MICROVILLI
“Microvilli, finger like cytoplasmic projections, increase surface area of plasma membrane thus increasing cell’s rate of absorption.”
microvilli
surface area
non-ciliated simple columnar epithelium E.g.
stomach to anus (digestive tract)
secrete/absorb
mucus secrete (goblet cell)
LUBRICATE
digestive/respiratory/urinary/genital tracts
PROTECT
from stomach acids (gastric juices)
ciliated simple columnar epithelium
E.g.
Bronchioles
Uterine tubes
uterus
ventricles of brain
cilia
beat in unison
move mucus
move foreign particles
cough up
swallow
spit out
move oocytes (immature ova)
expelled from ovary
through uterine tubes
to uterus
non-ciliated pseudostratified columnar
NO GOBLET CELLS
No cilia
nuclei various levels
appears stratified
Absorb/secrete
non-ciliated pseudostratified columnar epithelium E.g.
epididymis
vas deferens
male urethra some parts
…
larger ducts of many glands
epididymis
narrow tightly coiled tube attached to each of the testicles
sperm cells move from testicles to epididymis
vas deferens
connects epididymis to Urethra
ciliated pseudostratified columnar epithelium
have Cilia
have GOBLET cells
goblet cells secrete mucus
ciliated pseudostratified columnar epithelium E.g.
RESPIRATORY MUCOSA
respiratory tract
cilia, mucus, foreign particles
mucus traps foreign particles
cilia sweep away mucus
stratified squamous epithelium
cells in apical layer = squamous
cells in deeper layer =
cuboidal to columnar
basal cells divide, daughter cells push upward toward apical layer
NON-KERATINIZED stratified squamous
no KERATIN
moistened by mucus
surface cells shed before die
WHERE?
wet surface lining
lining of mouth
esophagus
pharynx
vagina
WHY?
Protect (abrasion)
(water loss)
(pathogen)
KERATINIZED stratified squamous
protein KERATIN
tough
WHERE?
Epidermis
hair
nails
WHY?
Protect (abrasion)
(water loss)
(pathogen)
(UV)
Stratified cuboidal
rare epithelial tissue type
WHERE?
Ducts of sweat glands
ducts of esophageal glands
WHY?
Protect
limited secrete/absorb