TIROIDES Flashcards

1
Q

proceso del adenoma de tiroides

A

neoplasia beninga de origen EPITELIAL!!!

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2
Q

epidemio del adenoma de tiroides

A

mujeres >50 años

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3
Q

etiopato del adenoma de tiroides

A

-adenoma funcional (caliente/ toxico): MUTACION TSRH !!!
-adenoma no funcionante (frio): MUTACION RAS o PIK3CA !!!

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4
Q

CC del adenoma de tiroides

A

-masa palpable, movil, indolora
-sintomas obstructivos: disfagia, disnea, ronquera

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5
Q

MACRO del adenoma de tiroides

A

lesion solida, encapsulada
*puede haber zonas de hemorragia, fibrosis, calcificacion

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6
Q

micro del adenoma de tiroides

A

-foliculos uniformes con bastante coloide separados por poco estroma
-CAPSULA FIBROSA

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7
Q

proceso de tiroiditis de Hashimoto

A

inmunopatologia HIPERSENSIBILIDAD 2!!!

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8
Q

epidemio de tiroiditis de Hashimoto

A

! MUJERES 45- 65 años
*causa #1 de hiperparatiroidismo NO asociada al yodo

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9
Q

etiopato de tiroiditis de Hashimoto

A

!!-anticuerpos anti-TIROGLOBULINA & ANTI-PEROXIDASA
*alteracion de la autotolerancia
!!-alteracion CTLA4 & PTPN22

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10
Q

CC de tiroiditis de Hashimoto

A

!!-hipoparatiroidismo (dism. de T3 & T4)
-Bocio indoloro

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11
Q

MACRO de tiroiditis de Hashimoto

A

glandula aumentada de tanmaño al incio y atrofia al final

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12
Q

micro de tiroiditis de Hashimoto

A

!!-infiltrado MN
!!-CENTROS GERMINALES
-atrofia de los foliculos tiroideos
*celulas de Hurtle/ oncocitos alrededor de los foliculos atrofiados

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