Tim Green

Question 1

What is a drug?

Answer 1

a chemical compound

Question 2

What is a medicine?

Answer 2

It contains a drug in a suitable formulation

Question 3

What does ADME stand for?

Answer 3

absorption, distribution, metabolism and excretion

Question 4

Source of the drug: willow tree

Answer 4

aspirin

Question 5

Source of the drug: chinchona

Answer 5

quinine

Question 6

Source of the drug: poppy

Answer 6

morphine

Question 7

Source of the drug: belladonna (deadly nightshade)

Answer 7

atropine

Question 8

Source of the drug: foxglove

Answer 8

Digitalis (treatment of heart failure)

Question 9

Source of the drug: coca

Answer 9

cocaine (led to local anaesthetics)

Question 10

Source of the drug: Marijuana

Answer 10

Cannabis

Question 11

Source of the drug: nicotinia

Answer 11

Nicotine

Question 12

Source of the drug: Yew

Answer 12

Paclitaxel(anticancer agent)

Question 13

Source of the drug: Pregnant mare’s urine

Answer 13

Premarin (menopause treatment)

Question 14

What was the earliest source of therapeutic agents?

Answer 14

natural products

Question 15

Which of these drugs was developed most recently?

a) antibiotics
b) anti-virals
c) arsenicals
d) beta-blockers

Answer 15

b

Question 16

What do agonists do?

Answer 16

bind to the receptor and cause a response

Question 17

what do antagonists do?

Answer 17

bind to the receptor. They have no effect themselves, but prevent agonists from binding and so therefore block the response.

Question 18

To which of the following are receptors NOT directly linked?
A.	G-proteins
B.	kinases
C.	ion channels
D.	phosphatases

Answer 18

D

Question 19

Where might an agonist bind?
A.	DNA
B.	enzyme
C.	receptor
D.	ion channel

Answer 19

C

Question 20

An agonist binds to its receptor and has

Answer 20

no effect

Question 21

What is L-DOPA used to treat?

Answer 21

Parkinson’s disease