Thyroiditis Flashcards

1
Q

def

A

inflammation of the thyroid

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2
Q

does thyroiditis cause high or low thyroid hormones

A

can be either

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3
Q

what are the common forms of thyroiditis

A
AUTOIMMUNE THYROIDITIS
1 Hashimoto's thyroiditis (most common)
2 past partum thyroiditis
3 silent or painless thyroiditis
NON-AUTOIMMUNE THYROIDITIS
1 de quervains thyroiditis AKA granulomatous thyroiditis
2 drug or radiation induced thyroiditis
3 acute or infectious thyroiditis
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4
Q

what is hashimotos thyroiditis

A

autoimmune condition in which the thyroid gland is slowly destroyed

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5
Q

what causes hashimotos thyroiditis

A

genetic and environmental factors which causes antithyroid antibodies which attack the thyroid

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6
Q

epi of hashimotos thyroiditis

A

most common cause of hypothyroidism

women>men

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7
Q

history + examination of hashimotos thyroiditis

A
history
-symptoms of hypothyroidism
examination
-signs of hypothyroidism
-painless goitre
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8
Q

investigations of hashimotos thyroiditis

A

antibodies against thyroid peroxidase

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9
Q

risk factors of hashimotos thyroiditis

A

family history of condition

autoimmune disease

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10
Q

management of hashimotos thyroiditis

A

levothyroxine

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11
Q

complications of hashimotos thyroiditis

A

thyroid lymphoma

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12
Q

prognosis of hashimotos thyroiditis

A

generally good

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13
Q

what is post-partum thyroiditis

A

observed after pregnancy which gives hyperthyroidism, hypothyroidism or the two sequentially

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14
Q

epi of post-partum thyroiditis

A

uncommon in post-partum women

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15
Q

aetiology of post-partum thyroiditis

A

due to changes in the immune system in pregnancy this causes antithyroid antibodies

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16
Q

prognosis of post-partum thyroiditis

A

known as the resolving thyroiditis

17
Q

history + examination of post-partum thyroiditis

A

hyperthyroidism usually occurs first followed by hypothyroidism (which is generally more severe so is when patients present)

18
Q

investigations of post-partum thyroiditis

A

a suppressed TSH could indicate the hyperthyroid phase

a low T3/4 with raised TSH could indicate the hypothyroid phase

19
Q

management

A

the hyperthyroid phase is generally quite mild and may require beta-blockers or nothing
the hypothyroid phase is more severe and if the TSH is very high, levothyroxine may be required

20
Q

silent or painless thyroiditis

A

inflammation of the thyroid gland
autoimmune reaction against the thyroid gland leading to hyperthyroidism followed by hypothyroidism
women>men
symptoms + signs of hyperthyroidism followed by symptoms + signs of hypothyroidism
TFTs

21
Q

what is de quervains thyroiditis

A

AKA as subacute granulomatous thyroiditis

it is painful thyroiditis

22
Q

aetiology of de quervains thyroiditis

A

can be preceded by URTI

viral causes include coxsackie, mumps, adenoviruses

23
Q

history + examination

A

hyperthyroid phase followed by a hypothyroid phase
symptoms of hyperthyroidism followed by symptoms of hypothyroidism
there may be painful dysphagia

24
Q

investigation

A

similar presentation to diffuse toxic goiter or graves disease
radionuclide thyroid uptake:
-decreased uptake in thyroiditis
-increased uptake in graves disease

25
Q

prognosis

A

a resolving thyroiditis

26
Q

what medications can cause drug induced thyroiditis

A

amiodarone

lithium

27
Q

features of drug induced thyroiditis

A

pain

28
Q

what is radiation induced thyroiditis

A

after radioactive iodine treatment for an overactive thyroid

the low levels of thyroid hormone after radioactive iodine is normally permanent

29
Q

features of acute or infectious thyroiditis

A

triggered by bacterial infection
pain in the throat, malaise
symptoms of hyperthyroidism, symptoms of hypothyroidism
antibiotics for infection

30
Q

a 62y/o man presents with AF. He has not noticed, tremors, heat intolerance, weight loss. His thyroid gland is non-nodular, non-tender, and slightly enlarged. Serum TSH is low, T4 and T3 are raised. He is positive for thyroid peroxidase antibodies, and there is a low radioiodine uptake.

A

thyroid peroxidase antibodies (hashimotos)
low radioiodine

thyroiditis