Thyroid Pathology Flashcards
Which is more likely to be a carcinoma:
hot or cold spots
cold (but still most likely to be benign)
Lid lag
when eyes move down, eye lid lags behind movement
because of hyperthyroidism
excessive sympathetic activation
sympathetics hold open eye lid
*other is from CNIII via levator palpibrae
Most common cause of hyperthyroidism in US
Grave’s disease
stimulatory anti-TSH receptor antibody
Most common cause of congenital hypothyroidism
iodine deficiency
Most common cause of hypothyroidism in US
Hashimoto thyroiditis
autoimmune destruction of thyroid gland
Etiology of thyroiditis
autoimmune destruction F>M
Hashimoto thyroiditis
etiology
consequences
autoimmune attack of thyroid gland
results in hypothyroidism
Antibody in Hashimoto thyroiditis
anti-peroxidase antibody
Hürthle cells seen in
Hashimoto thyroiditis
DeQuervain Thyroiditis
etiology
consequences
Tx
acute autoimmune thyroiditis after acute URI
*initially leads to transient hyperthyroidism as follicles destroyed and T4 released
*then hypothyroidism
self-limiting, let run course
Pathology findings of DeQuervain thyroiditis
multinucleated giant cells, ie foreign body giant cells
from colloid leaked from damaged follicles
Silent thyroiditis
silent, doesn’t cause problems
possible hyperthyroidism early
Reidel thyroiditis
etiology
findings
fibrosis of thyroid –> rock hard thyroid
rock hard neck mass, tracheal compression, hypothyroidism
Grave’s triad
hyperthyroidism
opthalmopathy w/ exopthalmos
dermopathy-pretibial thickening of skin
Iodine scan of Grave’s
diffuse increased uptake
1˚ hyperthyroidism
