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Endo/Repro Wk 1 > MEN Syndromes > Flashcards

MEN Syndromes Flashcards

1
Q

MEN1 gene

A

MEN1
menin, tumor suppressor gene
chromosome 11

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2
Q

MEN2A and MEN2B gene

A

RET
tyrosine kinase
in cells of neural crest origin

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3
Q

MEN1 tumors

A 
3Ps
pituitary tumors
parathyroid adenomas
pancreatic endocrine tumors
MEN1: menin, tumor suppressor gene
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4
Q

MEN2A tumors

A 
2Ps + medullary carcinoma
parathyroid hyperplasia
pheochromocytoma
medullary thyroid carcinoma
RET mutation: TK receptor in neural crest origin cells
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5
Q

MEN2B tumors

A

1P + medullary thyroid carcinoma + mucosal neuromas
pheochromocytoma
medullary thyroid carcinoma
mucosal neuromas
+ marfanoid habitus
RET mutation: TK receptor in neural crest origin cells

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6
Q

pituitary tumors
parathyroid adenomas
pancreatic endocrine tumors

A

MEN1

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7
Q

parathyroid hyperplasia
pheochromocytomas
medullary thyroid carcinoma

A

MEN2A

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8
Q

pheochromocytoma
medullary thyroid carcinoma
mucosal neurofibromas
marfanoid syndrome

A

MEN2B

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9
Q

RET mutation

A

TK receptor
mutated in MEN2A and MEN2B
activating mutation, turns on cells of neural crest origin

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10
Q

MEN1 mutation

A

MEN1: menin, tumor suppressor gene

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11
Q

What is the inheritance pattern of MEN syndromes

A

dominant

because then think they are dominant

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Endo/Repro Wk 1 (15 decks)

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