Thyroid Neoplasms Flashcards
What factors increase likelihood of malignancy?
Male
Solitary
Nodule is Cold
History of radiation
What cells will be seen on a slide if a fine needle aspiration is done for Hashimoto Thyroiditis?
Hurthle cells
If you just see follicle cells in the nodule, what are the two possibilities?
Cancer or just regular follicles
What is the most common neoplasm for thyroid cancer?
Adenoma
What are clinical symptoms for thyroid adenoma?
Most patients are euthyroid
Some hyperthyroid
What are lab test usually for thyroid adenoma?
TSH and T4 normal
Most adenomas “cold”
What is the usual morphology for thyroid adenoma?
Solitary
Encapsulated
No invasion
What is the usual mutation for thyroid adenoma
G-protein mutation
Gain of function mutation
What do you do if you see adenoma on a thyroid bx?
Take it out. Need the whole capsule to tell the two apart
What are the four types of thyroid carcinoma in order of decreasing prevalence?
Papillary (80%)
Follicular (10%)
Medullary (5%)
Anaplastic (<5%)
Who is most likely to get papillary thyroid carcinoma?
Female in 30s-50s
What is the prognosis for Papillary Thyroid Carcinoma?
Excellent (>95% 10y survival)
“Orphan Annie eye nuclei”
Papillary carcinoma
Who is most likely to get follicular thyroid carcinoma?
Female in 40s-50s
Where do follicular thyroid carcinomas usually spread?
Lung or bone
