Thyroid Disorders Flashcards
Hormone levels of Hypothyroidism
T3 + T4 ===> Reduced
FH4 ===> Reduced
TSH ===> Increased
Metabolism and Activity —> Reduced
Symptoms of Hypothyroidism
- fatigue
- weight gain
- constipation
- depression
- dry skin
- intolerance to cold
- menstrual irregularities
What is the treatment for Hypothyroidism
1st Line:
Levothyroxine
Alternative:
Liothyronine
What is the difference between Levothyroxine and Liothyronine
Liothyronine has a more rapid onset and more potent
(non uk brands may not be bio-equivalent)
What is the monitoring required for starting Levothyroxine
- monitor TSH every 3 months till stable then yearly
What point in the day should you take Levothyroxine
Morning 30 mins before food/drink
Why should you give similar brands for Levothyroxine and Liothyronine
because patients can experience side effects when switching
Hormone Level of Hyperthyroidism
T3 + T4 ===> Increased
FH4 ===> Increased
TSH ===> Reduced
Metabolism and Activity —> Increased
Symptoms of Hyperthyroidism
- hyperactivity
- Insomnia
- Heat Intolerance
- increased appetite
- weight loss
- Diarrhoea
- goitre (swollen thyroid glands)
What is the Treatment for Hyperthyroidism
1st Line:
Carbimazole
2nd Line:
Propylthiouracil
What are the MHRA warnings for Carbimazole
- Neutropenia
- Congenital Malformation
- Acute Pancreatitis
What should you be on while taking Carbimazole
Contraception (due to congenital malformation)
What should you report while taking Carbimazole
- Sore throat (neutropenia)
- severe abdominal pain (pancreatitis)
What can Propylthiouracil lead to
Liver Disorders
(jaundice, dark urine, nausea)
How to treat Hyperactivity symptoms of Hyperthyroidism
Beta Blockes
What is Grave’s Disease
an autoimmune condition where your immune system produces antibodies that cause the thyroid to produce too much thyroid hormone
How to treat Grave’s Disease
1st Line:
Radioactive Iodine
or
Carbimazole
Pregnancy and Hyperthyroidism Treatment: 1st Trimester
Propylthiouracil
Pregnancy and Hyperthyroidism Treatment: 2nd and 3rd Trimester
Carbimazole
