Thyroid and anti-thyroid drugs

Question 1

Thyroid drug exemplar

Answer 1

LEVOTHYROXINE

Question 2

antithyroid drug exemplar

Answer 2

PROPYLTHIOURACIL

Question 3

THYROID CLASSIFICATIONS

Answer 3

NATURAL (THYROID, THYROID DESICCATED) OR SYNTHETIC (LEVOTHYROXINE) T4

Question 4

ANTITHYROID CLASSIFICATIONS

Answer 4

• THIAMIDE DERIVATIVES

* PROPYLTHIOURACIL

Question 5

LEVOTHYROXINE MOVEMENT

Answer 5

PO ONSET 3-5 DAYS, PEAK 3-4 DAYS, ½ LIFE 5-10 DAYS, ACTION 1-3 WEEKS

Question 6

PROPYLTHIOURACIL MOVEMENT

Answer 6

PO ONSET 24-36 H, PEAK 1 H, ½ LIFE, 1.5-5 H, ACTION 2-3 H

Question 7

LEVOTHYROXINE ACTION

Answer 7

FUNCTION IN THE SAME MANNER AS ENDOGENOUS T4

Question 8

PROPYLTHIOURACIL ACTION

Answer 8

• INHIBITS THE INCORPORATION OF IODINE MOLECULES INTO THE AMINO ACID TYROSINE
WHICH IS REQUIRED TO MAKE THE PRECURSORS OF T3 AND T4
• IMPEDES THE FORMATION OF THYROID HORMONES

Question 9

LEVOTHYROXINE NURSING CONSIDERATIONS

Answer 9

• CONTRAINDICATIONS: ALLERGY, RECENT MI, ADRENAL INSUFFICIENCY, HYPERTHYROIDISM
• ADVERSE EFFECTS: USUALLY RELATED TO OVERDOSE, DYSRHYTHMIAS, TACHYCARDIA, PALPITATIONS, INSOMNIA, TREMORS, HEADACHE, ANXIETY, N/V, WEIGHT LOSS, SWEATING
• INTERACTIONS: MULTIPLE COMMON MEDICATIONS TABLE 32-3

Question 10

PROPYLTHIOURACIL NURSING CONSIDERATIONS

Answer 10

• CONTRAINDICATIONS: ALLERGY
• ADVERSE EFFECTS: LIVER AND BONE MARROW TOXICITY (LEUKOPENIA, THROMBOCYTOPENIA), BLEEDING, DROWSINESS, HEADACHES, N/V/D, RASH, PRURITUS, INCREASED CREATININE AND EGFR, MYALGIA, ARTHRALGIA

Question 11

LEVOTHYROXINE INDICATIONS

Answer 11

• REPLACEMENT OF TO ACHIEVE NORMAL THYROID LEVELS (EUTHYROID)
• REPLACEMENT POST THYROID REMOVAL OR DESTRUCTION FROM RADIOACTIVE IODINE
THERAPY FOR TREATMENT OF THYROID CA OR HYPERTHYROIDISM

Question 12

PROPYLTHIOURACIL INDICATIONS

Answer 12

• TREATMENT OF HYPERTHYROIDISM TO ACHIEVE NORMAL THYROID LEVELS (EUTHYROID)
• PREVENT THE SURGE IN THYROID HORMONES AFTER TREATMENT WITH RADIOACTIVE IODINE
THERAPY OR POST THYROID REMOVAL (FOR THYROID CA OR HYPERTHYROIDISM)

Question 13

LEVOTHYROXINE ADMINISTRATION

Answer 13

• PO/IM/IV

* GIVE PO ON EMPTY STOMACH FOR BEST ABSORPTION, IN THE AM (AVOID INSOMNIA)

Question 14

PROPYLTHIOURACIL ADMINISTRATION

Answer 14

• PO
• GIVE WITH MEALS TO DECREASE GI UPSET; MONITOR FOR S&S BONE MARROW OR LIVER
FAILURE (FEVER, SORE THROAT, MOUTH ULCERS, JAUNDICE, BLEEDING, BRUISING)