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IP week 13 endocrine > Thyroid and Adrenal Pharmacology > Flashcards

Thyroid and Adrenal Pharmacology Flashcards

1
Q

Regions of Adrenal Gland

A

adrenal cortex adrenal medulla

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2
Q

Adrenal Cortex

A

synthesizes/secretes steroids essential for salt balance metabolism androgenic actions

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3
Q

Adrenal Medulla

A

synthesizes/secretes catecholamines for sympathetic regulation

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4
Q
A
  1. zona glomerulosa
  2. Ang 2/K
  3. ACTH
  4. Zona fasciculata/reticularis
  5. aldosterone synthase
  6. aldosterone
  7. 11 B-hydroxylase
  8. 17 a-hydroxylase
  9. cortisol,androgens
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5
Q

Glucocorticoids ex.

A

cortisol

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6
Q

mineralcorticoids ex.

A

aldosterone

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7
Q

Glucocorticoid effects

A

metabolic effects

  • increase BG (inhibit insulin/glucose neogenesis)
  • increased AA (muscle catabolism)
  • increased TG (lipase action in adipocytes)

anti-inflammatory effects

  • inhibit cytokine release from immune cells (inhibit kB)
  • regulate transcription of pro-inflammatory proteins

Immune response

  • inhibit leukocyte
  • inhibit wound healing
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8
Q

list of 6 pro-inflammatory proteins and recepters

A

Phospholipase A

COX2

Prostaglandins

Leukotrienes

IL-1,2,3,6,8

TNF-a

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9
Q

mineralcorticoid effects

A

electrolyte and water balance

  • incrased Na retention, K and water excretion
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10
Q

Synthesis fo Adrenocortical hormones

A

Cholesterol is primary begining molecule

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11
Q

what steroid circulates at higher concentrations than aldosterone

A

cortisol

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12
Q

2 types of receptors for steroids

A

Type 1: mineralcorticoid

  • kidney

Type 2: glucocorticoid

  • tissues
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13
Q

Both aldosterone and cortisol bind to aldosterone and cortisol receptors with high affinity. so how to cell/tissue types regulate their actions?

A

11 B-HSD 1 reduces 11-C position to -OH in liver

11 B-HSD2 oxidizes 11-C position to C=O in kidney

*hydroxyl group is critical for cortisol activity so is it deactivated in kidneys so aldosterone is the only activite constituent in kidney

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14
Q

NF-kB

A

transcription facor in all cell types involved in cellular responses to stress, cytokines, free radicals, UV, bacteria, viral antigens

  • first responders to harmful stimuli
  • inducers include: ROS, TNF-a, IL-1, LPS, radiation
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15
Q

Mineralcorticoid MOA

A

regulates BP by acting on distal tubules and CD of nephron, increasing reabsorption of Na and water, and secretion of K

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16
Q

Relation of potency and DOA of G

A
  1. affinity to transcortin
  2. affinity for 11 B-HSD2
  3. lipophilicity
  4. Affinity for receptor

IP week 13 endocrine (8 decks)

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