G Vs M Flashcards

1
Q

3 keto 4 ene

A

G and M required

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2
Q

20 keto group

A

G and M required

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3
Q

21 oh

A

Required for M not essential G

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4
Q

18 formyl

A

High increase M

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5
Q

11 B-OH

A

Required to be active for G not required for M

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6
Q

17 a-OH

A

Increase G decrease M

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7
Q

1-ene

A

Increase G decrease M

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8
Q

6 a-CH3

A

Increase G decrease M

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9
Q

16 a-OH

A

High decrease M

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10
Q

16 a-CH3

A

High decrease M

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11
Q

16 B-CH3

A

High decrease M

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12
Q

16 a, 17 a-metal

A

High decrease M

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13
Q

9 a-F

A

Increase G and M

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14
Q

9 a-Cl

A

Increase G and M

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15
Q

21-Cl

A

Increase topical activity

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16
Q

6 a-F

A

Increase G but not as much as 9

17
Q

A ring aromatic and 3-OH

Phenol

A

E

18
Q

D ring c17 HBA

A

E

19
Q

Distance 10-12 A

A

E

20
Q

1 or 4 sub on __ does __

A

E and inactivates

21
Q

2-OMe or 2-F on __ does __

A

E and decrease activity to 2-5%

22
Q

B ring unsaturated on __ does __

A

E decreases activity

23
Q

11 B-OMe or 11 B-Et on__ does __

A

E increase activity

24
Q

6,7 double bond on __ does __

A

P increases

25
Q

6-Me or 6-X on __ does __

A

P increases

26
Q

11-Me on __ does __

A

P increases

27
Q

21–F on__ does __

A

P increase oral effectiveness

28
Q

17a-alkynyl on__ does __

A

P increases

29
Q

18-Me to 18-Et on __ does __

A

P increases A decreases