Thyroid Flashcards
Type I deiodinase
Outer ring and inner ring
PRIMARY source of T3 in circulation
Liver, kidney, thyroid, skeletal muscle
Type II deiodinase
Outer ring
Makes T3 and rT3
Pituitary senses these levels and gives feedback
Brain, pituitary, placenta, cardiac muscle
Type III deiodinase
Inner ring
Only makes rT3
Brain, placenta, skin
BMR
Hypothyroid
Overall decreased
Carbohydrate metabolism
Hypothyroid
DEC gluconeogenesis
DEC glycogenolysis
Normal serum glucose
Protein metabolism
Hypothyroid
DEC synthesis
DEC proteolysis
Lipid metabolism
Hypothyroid
DEC lipogenesis
DEC lipolysis
IN serum cholesterol
Thermogenesis
Hypothyroid
Decreased
cold intolerant
BMR
Hyperthyroid
Overall increased
Carbohydrate metabolism
Hyperthyroid
IN gluconeogenesis
IN glycogenolysis
Normal serum glucose
Protein metabolism
Hyperthyroid
IN synthesis
IN proteolysis
Muscle wasting
Lipid metabolism
Hyperthyroid
IN lipogenesis
IN lipolysis
DEC serum cholesterol
Thermogenesis
Hyperthyroid
Increased
heat intolerant