GH/IGF-I Flashcards

1
Q

GH Effect on Adipose

A

DEC Glucose uptake
IN Lipolysis

Overall: DEC Adiposity

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2
Q

GH Effect on Liver

A
IN RNA synthesis
IN Protein synthesis
IN Gluconeogenesis
IN IGFBP
IN IGFs

Overall: Create IGFs

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3
Q

GH Effect on Muscle

A

DEC Glucose uptake
IN AA uptake
IN Protein synthesis

Overall: IN Lean body mass

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4
Q
IGF-I Effect on;
Kidney
Pancreas
Intestine
Islets
Parathyroids
Skin
Connective Tissue
Bone
Heart
Lung
A

IN Protein synthesis
IN RNA synthesis
IN DNA synthesis
IN Cell size and number

Overall: IN Organ size
IN organ function

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5
Q

IGF-I Effect on Chondrocytes

A
IN AA uptake
IN Protein synthesis
IN RNA synthesis
IN DNAA synthesis
IN Collagen
IN Chondroitin sulfate
IN Cell size and number

Overall: IN Linear growth

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6
Q

GH Stimulators

A
GHRH
Dopamine
Norepi/Epi (exercise/stress)
AA (protein building)
Thyroid hormone

Stress, exercise, starvation

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7
Q

GH Inhibitors

A

SS
IGF-I
Glucose (hyperglycemia)
FFA (obesity)

Decreased with aging, high blood glucose, obesity

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