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Endocrine > HPA > Flashcards

HPA Flashcards

1
Q

Highest ACTH affinity receptor

A

MC2R

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2
Q

Immediate effects of ACTH

A 
IN Cholesterol esterase
DEC Cholesterol ester synthetase
IN Cholesterol transport into mitochondria
IN Cholesterol binding to p-450SCC
IN Pregnenolone production
IN StAR protein
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3
Q

Subsequent effects of ACTH

A

IN Gene transcription of P-450SCC, P-450 C17, P-450 C11
Adrenoxin
LDL receptor
HDL receptor

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4
Q

Long-term effects of ACTH

A

IN size and functional complexity of organelles
IN Size and number of cells

Long term binging: adrenal hypertrophy

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5
Q

Pleiotropic effects of cortisol

Muscle

A

Maintain muscle function

Decrease muscle mass

Inhibits GLUT4 insertion into the membrane; decreases glucose uptake into muscle cells

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6
Q

Pleiotropic effects of cortisol

Bone

A

Decrease bone formation

Increase bone resorption

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7
Q

Pleiotropic effects of cortisol

Connective tissue

A

Decrease connective tissue

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8
Q

Pleiotropic effects of cortisol

Immune

A

Inhibit inflammatory and immune responses

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9
Q

Pleiotropic effects of cortisol

Cardiovascular

A

Maintain cardiac output

Increase arteriolar tone

Decrease endothelial permeability

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10
Q

Pleiotropic effects of cortisol

Pregnancy

A

Facilitate maturation of the fetus

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11
Q

Pleiotropic effects of cortisol

Kidney

A

Increase glomerular filtration and free water clearance

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12
Q

Pleiotropic effects of cortisol

Brain

A

Modulate emotional tone

Modulate wakefulness

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13
Q

Zona glomerulosa

A 
Top
Mineralcorticoids (aldosterone)
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14
Q

Zona fasciculata

A

Middle, largest layer

Glucocorticoids (cortisol)

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15
Q

Zona reticularis

A 
Bottom
Weak androgens (DHEA)
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16
Q

Cortex

A

Mesoderm tissue
Steroid hormones
All the Zonas

17
Q

Medulla

A

Neural tissue

Catecholamines

Endocrine (7 decks)

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