Hypothalamic Releasing Factors

Question 1

GnRH (peptide) IP3/DAG/PKC

GnIH (inhibitor)

Answer 1

Brain Nuclei: Scattered, POA has majority
Pit. Target: Gonadotropes - FSH, LH
Function: Reproduction

Question 2

CRH (peptide)

cAMP

Answer 2

Brain Nuclei: PVN (parvocellular)
Pit. Target: Corticotrope - ACTH
Function: Glucorticoids - pleiotropic effects

Question 3

TRH (peptide)

IP3/DAG/PKC

Answer 3

Brain Nuclei: PVN
Pit. Target: Thyrotrope - TSH
Function: Thyroid hormone -pleiotropic effects

Question 4

GHRH (peptide)

cAMP

Answer 4

Brain Nuclei: Arcuate nucleus
Pit. Target: Somatotrope - GH
Function: Growth and development

Question 5

Somatostatin (GHRH inhibitor)

cAMP

Answer 5

Brain Nuclei: Periventricular (PeVN)
Pit. Target: Somatotrope
Function: Inhibits GH

Question 6

Dopamine (amine)

Answer 6

Brain Nuclei: Arcuate nucleus
Pit. Target: Lactotrope - prolactin
Function: Milk production