Thrombosis and risk factors for thrombosis

Question 1

Venous thromboembolism

-1 and 2 prevention

Answer 1

Epidemiology: 1/1000 pop, 20% PE = sudden death
Diagnosis: D-dimer blood test and doppler ultrasound exam of legs. blood tests to look at clotting factors
Prevention: 1) blood thinning meds
2) monitor with ultrasound
Management: pressure stockings, low dose low molecular weight heparin eg fondaparinix / long term warfarin

Question 2

Inherited

Acquired- risk facotors for venous thromboembolism

Answer 2

• inherited = known thrombophillias eg anti thrombin deficiency, protein C & S, activated protein X resistance, dysfibrinogenaemia
  Acquired = 60+, dehydration, trauma, HRT, varicose veins, antiphospholipid syndrome, pregnancy

Question 3

Risk factors for arterial thrombosis

Answer 3

smoking, hypetension, hypercholesterolaemia, diabetes, fx, obesity, male, Factor 5 leiden.