Thrombosis Flashcards
Which is more likely to be formed of platelets- arterial or venous thrombosis?
Arterial
Which is more likely to be formed of fibrin- arterial or venous thrombosis?
Venous
What is the most common inherited thrombophilia?
Factor V Leiden
In factor V Leiden, a single point mutation has what effect?
Factor V is less efficiently switched off by protein C
What is the most common condition causing acquired thrombophilia?
Anti-phospholipid syndrome
What medication is particularly known for increasing the risk of venous thrombosis?
Combined oral contraceptive pill
If an individual has a recurrence of VTE while on warfarin, what should be done?
Increase INR to 3-4 and continue lifelong
Protein S and protein C are responsible for cleaving and neutralising what clotting factors?
V and VIII
What abnormality may be seen on a full blood count of someone with anti-phospholipid syndrome?
Mild thrombocytopenia
Which thrombophilia may paradoxically be associated with a prolonged APTT?
Anti-phospholipid syndrome
What medication is the first line treatment for the majority of individuals with VTE?
NOACs
What is the first thing to do if you suspect that a patient has a DVT?
Calculate their Well’s score
If a patient has a Well’s score of 2 or more (DVT likely), what is the first line investigation and in what timeframe should it ideally be offered?
Ultrasound within 4 hours
If a patient with suspected DVT undergoes an ultrasound and the result is positive, what should be done next?
Therapeutic dose of anticoagulant
If a patient with suspected DVT undergoes an ultrasound as a first line investigation and it is negative, what should be done next?
D-dimer measurement
