thrombosis

Question 1

describe the use of LMWH to treatment VTE

Answer 1

doses fixed by body weight
usually once a day by S/C injection
treat for at least 5 days
overlap with warfarin until INR >2.0 for 2 consecutive days

Question 2

what are the advantages of the newer oral anticoagulants

Answer 2

predictable pharmacokinetics with no monitoring needed
dose is uniform for most patients (varies 40 fold with warfarin)
rapid onset of action, now need for LMWH

Question 3

which new oral anticoagulant is a direct thrombin inhibitro

Answer 3

dabigatran

Question 4

which new oral anticoagulants have direct anti-Xa activity

Answer 4

rivaroxaban
apixaban
endoxaban

Question 5

which parenteral anticoagulants are anti-Xa?

Answer 5

fondaparinux

LMWH

Question 6

which parenteral anticoagulants are anti-thrombin

Answer 6

argatroban

bivalirudin