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Haematology > paediatric haematology > Flashcards

paediatric haematology Flashcards

1
Q

which chromosome produces alpha haemoglobin

A

chromosome 16

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2
Q

which chromosome produces beta haemoglobin

A

chromosome 11

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3
Q

which haemoglobin chains does chromosome 16 produce

A

zeta and alpha

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4
Q

which haemoglobin chains does chromosome 11 produce

A

e, gamma, beta, delta

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5
Q

name the 3 foetal Hbs from 4 to 14 weeks gestation

A

Hb Gower-1
Hb-Portland
Hb Gower-2

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6
Q

what are the 4 chains in Hb Gower-1

A

zeta2, e2

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7
Q

what are the 4 chains in Hb Portland

A

zeta2, gamma2

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8
Q

what are the 4 chains in Hb Gower-2

A

alpha2, e2

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9
Q

which haemoglobin is formed at 14 weeks gestation

A

HbF a2 y2

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10
Q

what percentage of haemoglobin is foetal haemoglobin at birth

A

55-65%

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11
Q

when does foetal haemoglobin become like adult haemoglobin?

A

around 3 months

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12
Q

what is HbA

A

a2b2

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13
Q

what is HbA2 and who has it

A

a2d2 some with thalassaemia

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14
Q

when do platelets reach adult numbers

A

18 weeks gestation

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15
Q

what are the 2 different functions of platelets at birth

A

hyporesponsive to certain agonists

hyperresponsive to vwf

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16
Q

which antibody crosses the placenta

A

IgG

17
Q

which antibodies are found in mothers breast milk

A

IgA, IgM, IgG, IgD, IgE

18
Q

when do babies start producing their own antibodies

A

2-3 months

19
Q

when do babies have the same number of antibodies as adults

A

around 6 months

20
Q

which are the 4 normal haemostasis proteins

A

FV, FVIII, FXIII, fibrinogen

21
Q

which pro-coagulant factors are reduced

A

1972 and prekallikrein and HMW kininogens

22
Q

which clotting factors have unique forms

A

fibrinogen plasminogen

23
Q

babies have raised levels of….involved in haemostasis

A

D-dimers, vWF

24
Q

what percentage of mother vitamin K do babies have

A

10%

25
Q

what illness are babies at risk of getting due to low vitamin K

A

haemorrhagic disease of the newborn

Haematology (5 decks)

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