Thrombosis Flashcards
1
Q
What are the inhibitors of coagulation?
A
Antithrombin 3 - protease
Protein C and Protein S - Co-factor
Plasminogen - breaks down fibrin clots
2
Q
Acquired venous thrombosis is down to 11 factors:
A
- Age
- Previous thrombosis
- Immobilisation
- Surgery
- Malignancy
- Oral Contraceptives
- HRT
- Antiphospholipid antibody syndrome
- Essential thrombocytosis or thrombocythaemia
3
Q
what is the proposed mechanism of hyper coagulable effect of aPL Ab?
A
- complement activation
- production of Ab against coagulation factors
- activation of platelets
- activation of vascular endothelium
- reaction of Ab to oxidised low-density lipoprotein
