Thrombophilias Flashcards

1
Q

Acquired

A

Estrogen therapy, adv age, obeisity, smokeing

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2
Q

AT3 Def

A

norm neuts activated serine proteases and inhibs coag by binding to thrombin and amp’d by Hep. Lab = no prolonged PTT after Hep dosage.

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3
Q

Protein C Def

A

Normally prod in liver, vit K dep, degrades 5a and 8a with Prot S cofact. Thrombosis occurs and less than 50 percent available. Increased risk for warfarin skin necrosis.

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4
Q

Protein S def

A

Active when free (bound to C4b). May decrease with vit K def, warf, liv desease. Increased consumption in acute thrombsis, DIC, MPD, Sickle

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5
Q

Homocysteine

A

Def of cystathione beta and 5,10methylTHF reductase. Leads to art and venous thrombosis, mental retard, long fingers.

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6
Q

F5 Leiden

A

Freq DVT, Arg to Guanin on F5 so APC can’t degrade. Diag = coag test

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7
Q

Prothrombin 20210A

A

Slowed mRNA degrade of circ prothrombin. Assoc with increased number of miscarriages.

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8
Q

AntiPL Syndrome

A

AID assoc with SLE, RA, Sjo, HIV. Anti-pl Abs to plasma proteins. Induces hypercoag due to endo inj. APAs include anti-cardiolipin, lupus anticoag, antiGp1b.

Clin - repeat spont aborts, stroke, DVT

Lab = False Syphalis pos, Inc PTT without correction

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