Secondary Hemostasis

Question 1

vWD

Answer 1

most common, spont bleeds

Question 2

Type 1 vWD

Answer 2

mild to mod def, incomplete pen, AD, DDAVP tx

Question 3

Type 3 vWD

Answer 3

very low lvls of vWF, Severe bleeding, treat with factor concentrate

Question 4

Type 2a VWD

Answer 4

Normal number, def missense of multimer assembly. DDAVP tx

Question 5

Type 2b vWD

Answer 5

Loss of large multimers and thrombocytopenia. F8 Conc tx, DDAVP induces thrombocytopenia

Question 6

vWD Labs

Answer 6

Inc PTT, corrects on mixing. Ristocetin cofactor activity (antibiotic which induces vWF binding and agglutination) mix with platelets, pt serum, and risto and measure agglut

Question 7

Hemo A

Answer 7

F8. Inverted X>pt mutation. Inc PTT, corrected on mix. Tx = recomb F8

Question 8

Hemo B

Answer 8

F9 def

Question 9

Coagulation Factor Inhibitor

Answer 9

Acquired Ab against coag factors. Sim to Hemo A but doesnt correct on mixing

Question 10

Vit K def

Answer 10

Gamma carboxylation decreased, Activated by epoxide reductase and disrupts factors 2,7,9,10 Prot C/S.

Question 11

Liver Fail

Answer 11

Decreases coag factors and follow with PT