Thrombophilia and Coagulopathy Therapy

Question 1

anticoagulants

Answer 1

heparin, warfarin, LMWH, Antithrombins, anti-Xa

prevent arterial and venous thrombosis

Question 2

antiplatelet drugs

Answer 2

prevent arterial thrombosis

Question 3

fibrinolytics

Answer 3

lyse arterial and venous thrombi

Question 4

types of arterial thrombosis

Answer 4

stroke, MI, peripheral artery occlusion

Question 5

types of venous thrombosis

Answer 5

DVT, PE (pulmonary embolism)

other: intracranial, intra-abdominal/pelvic, upper extremities

Question 6

types of embolic disease

Answer 6

related to atrial fibrillation or valvular heart disease

Question 7

reasons for anticoagulation

Answer 7

prevent: extension of clot from calf into thigh, PE, recurrence, phostphlebitic syndrome, emboli from atrial fibrillation and mechanical heart valves

Question 8

LMWH

Answer 8

SC: 1-2x/day ( 1mg/kg q12h)
no monitoring needed
use: therapeutic and prophylactic
enoxaparin, dalteparin, tinzaparin, fondaparinux
long T1/2
no antidote 
Montor with Xa assay: does NOT prolong PTT
do NOT use in renal therapy

Question 9

indications for heparins

Answer 9

1. immediate interruption of coagulation
2. maintain anticoagulation in first week of warfarin therapy
3. maintain potency of indwelling lines
4. prevent clotting of hemodialysis unit and during open heart surgery
5. prevention of DVT