Pictures Flashcards
normal red blood cells
eosinophil
basophil
monocyte
lymphocyte
lymphocyte
reactive lymphocyte
large granular lymphocyte
(NK cell or cytotoxic T cell)
neutrophil
left shift: neutrophil variants
horseshoe nuclei: band
bean nuclei: metamyelocytes
round nuclei: myelocyte
neutrophil with toxic granulation
platelet
giant platelet
Describe RBC
normocytic, normochromic RBC
Describe RBC
hypochromic RBC
Describe RBC
Hypochromia, anisocytosis, poikilocytosis
polychromasia
sickle cell
Bite cells and hemoglobin clumps
schistocytes
blast
promyelocyte
myelocyte
metamyelocyte
band
pronormoblast
basophilic erythroblast
polychromatophilic
normochromic erythroblast
immature megakaryocyte
mature megakaryocyte
bone marrow core biopsy (5 year old)
bone marrow core biopsy (35 years old)
bone marrow core biopsy
top circle: erythroid
bottom circle: myeloid
arrow: megakaryoctye
normal bone marrow
Describe.
Name.
- microcytosis, hypochromia, anisocytosis, poikilocytosis
- Iron deficiency
Describe.
Name.
- microcytosis, hypochromia, target cells
- beta thalasemia
Describe.
Name.
- impaired nuclear maturation indicated by red nucleus, enhanced cytoplasm
- meagaloblastic RBCs
What is this and what causes it?
- megoblastic anemia
- impaired B12 uptake, folate deficiency, some drugs, bone marrow dysfunction
Describe.
Name.
- normocytic, iron
- anemia of chronic infection
Describe.
Name.
- spherocytes
- hereditary spherocytosis
Describe.
Name.
- hemoglobin crystals
- Hemoglobin C disease
polychromasia (increased reticulocytes)
Describe.
Name.
- heinz bodies
- G6PD deficiency
- cell that looks like it has a blister
- G6PD deficiency
- Left arrows
- Upper right arrows
What is this?
- merozoites
- gametocyte
- Plasmodium falciparum
Plasmodium vivax
babesia
Bartonella bacilliformis
Bartonella bacilliformis
C. perfringens
Warm autoimmune hemolytic anemia
Warm autoimmune hemolytic anemia
Describe.
Name.
- red cell agglutination
- cold autoimmune hemolytic anemia
Describe.
Name.
- schistocytes
- microangiopathic hemolytic anemia due to thrombotic thrombocytopenia purpura
hypersegmented neurtrophil
megaloblastic anemia
megaloblastic anemia
A and C: abnormally large erythroid progenitors
B: megaloblast
Iron Deficiency
hemochromatosis
angular cheilosis: ulceration at corners of mouth
iron-deficiency
koilonychia: spooning nails (concave, rigid, brittle)
iron-deficiency
glossitis: bald fissured appearance caused by flattening and loss of papillae
Iron-deficiency
iron deficiency:
hypochromic, microcytic, poikilocytes, pencil cells, occasional target cells, plenty of platelets
Bone marrow: Perl’s stain
normal iron stores: blue
Bone marrow: Perl’s stain
iron deficiency
no hemosiderin
inset: no siderotic granules in erythroblasts
bronzing of skin: due to iron in melanin
hemachromatosis
lots of iron in hepatocytes
hematochromatosis
ring sideroblasts with perinuclear ring of iron granules
sideroblastic anemia
lead poisoning
causes sideroblastic anemia
basophilic stippling: precipitated RNA in RBC
pallor and mild icterus
megaloblastic anemia
Glossitis: beefy, red, painful
Megaloblastic anemia: folate deficiency and B12 deficiency
Macrocytic RBC
hypersegemented neutrophil
megaloblastic anemia
Cracked Erythroblast: megaloblastic anemia
demyelation of the lateral (pyrimidal) and posterior columns
B12 deficiency: severe neuropathy at this stage
sickle cell anemia
top: Spleen in sickle cell disease (low power). Red pulp cords and sinusoids are markedly congested; between the congested areas, pale areas of fibrosis resulting from ischemic damage are evident.
bottom: Under high power, splenic sinusoids are dilated and filled with sickled red cells.
infarcted spleen due to sickle cell anemia
Thalassemia. X-ray film of the skull showing new bone formation on the outer table, producing perpendicular radiations resembling a crewcut.
facial abnormalities seen in beta thalassemia
bossing of skull, hypertrophy of maxilla, exposing upper teeth, depression of nasal bridge, periorbital puffiness
Expanded marrow in Skull: Beta thalassemia
osteoporosis: Beta thalassemia
splayed teeth due to widening of the maxilla and mandible
Beta thalassemia
Beta thalassemia
pallor, short, massive spleen, wasted limbs
ulcer: can occur in all types of hereditary anemias including sickle cell, B-thalassemia, hereditary spherocytosis
B-Thalassemia major
nucleated RBC, microcytosis, hypochromasia, target cells, teardrop cells, fragments, basophilic stippling
patient short of breath: look for heart failure due to iron load (freq. transfusions)
thalassemia trait
microcytosis, hypochromasia, target cells, teardrop cells, rare fragments
low MCV/MCh and increased RDW helps distinguish from iron deficiency
B-Thalassemia
fibrosis in portal tracts and nodular regeneration of hepatic parencymal cells, lots of iron
B-Thalassemia with pre-existing hep Ccarcinoma on left, and hepatic cirrhosis on right
hepatomegaly, heart failure, splenomegaly, edema, die
hydrops fetalis (gamma4)
alpha-thalassemia: HbH
deposits: precipitated alpha globin chains and golf ball cells
HbH
right: inclusion body (golfball with deposits-> beta tetramers)
left: reticulocyte
HbH
microcytosis, hypochromasia, target cells, microspherocytes, fragments, some basophilic stippling may occur
sickle cell anemia
deep stained sickle cells, target cells, polychromasia, hypochromic
sickle cell anemia
left: dactylitis
right: leading to shortened fingers in adulthood
sickle cell anemia
shortened finger due to dactylitis in childhood
sickle cell anemia
right middle metacarpal bone shortened due to infarction of growing epiphysis in childhood
pelvis necrosis, flattening of femoral heads
sickle cell anemia
sickle cell anemia: chest syndrome
alveolar edema and fat cell embolism
Sickle Cell/ hemoglobin C disease
teleangiectasia: vascular malformations on face, lips and hands
can get in iron deficiency
iron deficiency
smooth, shiny, red tongue and koilonychia (spoon nails)
normal RBCs
target cells
acanthocytes: spur cells
echinocytes: burr cells
dacrocytes: tear drops
spherocytes
ovalocytes
blister cells at arrows
bite cells
schistocytes
sickle cells
dehydration effect of RBC
Howell-Jolly bodies
nucleated RBC precursors
pappenheimer bodies
trophozoites of Plasmodium vivax
coarse basophilic stippling of lead poisoning
heinz bodies in person with spleen removed
B12 deficiency
giant hypersegemented neutrophil
hypersegmented neutrophils from antifolate chemo
myelodysplastic syndrome
dysplastic neutrophil (pseudopelgeroid cell)
degenerating neutrophil
