Leukemia/Lymphoma drugs

Question 1

AML induction

Answer 1

daunorubicin (top II intercalation), cytarabine (ARA-C: antimetabolite) and can add thioguanine (antimetabolite)

Question 2

post remission: AML

Answer 2

ARA-C

autologous bone marrow transplant

Question 3

APL induction

Answer 3

ATRA

arsenic trioxide

Question 4

Childhood APL induction

Answer 4

ATRA, arsenic

anthracycline +/- cytarabine

Question 5

APL maintenance

Answer 5

ATRA, 6-MP and methotrexate

Question 6

BBW: arsenic trioxide

Answer 6

CV problems: AV block, QT prolongation

leukocytosis, APL differentiation syndrome

Question 7

ALL induction

Answer 7

prednisone, vincristine, anthrcycline

Question 8

ALL: Ph1 positive

Answer 8

imatinib +/- chemo

Question 9

ALL: CNS prophylaxis

Answer 9

IT methotrexate

Question 10

ALL: consolidation

Answer 10

methotrexate and mercaptopurine

Question 11

-nib

Answer 11

bind ATP binding site (important for resistance)

Question 12

CML

Answer 12

imatinib is first line

Question 13

CML list of drugs

Answer 13

busulfan, cyclophosphomide, cytarabine, mechlorethamine, hydroxyurea
IFN-2a
nilotinib, dasatinib, imatinib

Question 14

ALL list of drugs

Answer 14

corticosteroid
daunorubicin, daunorubicin
mercaptopurine, methotrexate
vincristine

Question 15

CLL

Answer 15

fludarabine, rituximab, cyclophosphamide

EPO: for the anemia from treatment

Question 16

Hodgkin lymphoma

Answer 16

mitotic spindle inhibitor, anthracycline, DHFR inhibitor (or topo inhibitor), corticosteroid
combinations of these

Question 17

Non-Hodgkin lymphoma

Answer 17

rituximab (look at slide)
cyclophosphomide, doxirubicin, vincristine, prednisone
R-CHOP

Question 18

tositumomab

Answer 18

radionucleotide anti CD20 Ab

Question 19

ibritumomab

Answer 19

radionucleotide anti CD20 Ab

Question 20

BBW: pegaspargase

Answer 20

Erwinia hypersensitivity

Question 21

BBW: ATRA

Answer 21

APL differenetiation syndrome, leukocytosis

Question 22

BBW: bleomycin

Answer 22

lung fibrosis

Question 23

BBW: Busulfan

Answer 23

bone marrow suppression, secondary malignancy

Question 24

BBW: carboplatin

Answer 24

anemia, infection, kidney

Question 25

BBW: chloarambucil

Answer 25

bone marrow suppression, secondary malignancy, pregnancy, infertitlity

Question 26

BBW: anthracyclines (daunorubicin, doxirubicin, idarubicin)

Answer 26

heart, extravasional necrosis

Question 27

BBW: hydroxyurea

Answer 27

secondary malignancies

Question 28

BBW: IFN alpha-2b

Answer 28

CI: autoimmune, cardiac disease | suicide, depression

Question 29

BBW: mechlorethamine

Answer 29

pregnancy

Question 30

BBW: vincas

Answer 30

peripheral neuropathy (pins and needles)

Question 31

BBW: ozogamicin

Answer 31

BM, hepatic, pulmonary, infusion rxn

Question 32

BBW: nilotinib

Answer 32

CI: hypokalemia and hypomagnesemia | QT prolong

Question 33

BBW: ibritumomab, tiuxetan

Answer 33

exfoliate dermatitis, infusion rxn

Question 34

BBW: tositumomab

Answer 34

iodine hypersensitivity, thrombocytopenia, neutropenia

Question 35

BBW: rituximab

Answer 35

exfoliate dermatitis, infustion rxn, progressive multifocal leukoencephalopathy

Question 36

BBW: doxirubicin

Answer 36

cumulative dose | cardiac