Thrombophilia

Question 1

Defin

Answer 1

Coagulopathy makes you predisp to thrombosis, us venous eg DVT, PE.
Care if surg, preg, enforced rest. Also obesity, immobil, trauma, malig.

Question 2

Cause

Answer 2

-inherited-
Activated prot C
Prothrombin mut
Prot C and S defic
Antithrombin defic
-acquired- 
3rd gen progesterones
Anti Plip synd

Question 3

Investig

Answer 3

FBC, film, clotting, APC resis, lupus, antiocag Ab, prot C/s/antithrombin assays

Question 4

Mx

Answer 4

Heparin for acute thrombosis
Warfarin if recurrence, often for life.
Monit for skin necrosis due to warfrarin if prot C/S defic.
RF avoidance ge smok, HTN, hyperlip, DM, surg, trauma, immobil, preg, contracep, age, obesity, varicose veins, HF, malig, IBD, PND, nephrotic synd.