Non Hodgkins Lymphoma

Question 1

Defin

Answer 1

All lymphomas without reed sternberg cells.

Most B cell derived. Diffuse large B cell lymphoma most comm.

Question 2

Cause

Answer 2

Immunodefic eg drugs, HIV
HTLV 1
H pylori
Toxins
Congenital

Question 3

Px

Answer 3

Nodal dis, superfic lymphadenop.
Skin inv in T cell lymphoma
Waldeyers ring lymphoma obstruc breathing and sore throat.
Gastric MALT due to Hp fever and sweat.
Small bowel lymphoma GI symps.
Sys- fever, nigth sweat, wl
Pancytopenia- anaemia, infec, bleeding as low pl.

Question 4

Investig

Answer 4

Bloods incl high LDH
Marrow and node biop
Ann arbour staging
Cytology

Question 5

Mx

Answer 5

Radiotherapy for local
Chlorambucil for diffuse
Alpha IFN or rituximab to maint remiss. 
Bendamustine
RCHOP for high grade- rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine, prednisolone. 
G CSFs