Acute Myeloid Leuk

Question 1

Defin

Answer 1

Neop prolif of blasts derived from marrow myeloid elements.
Rapid progression
Most comm acute leuk in adults.

Question 2

Cause

Answer 2

Chemo for lymphoma LT
Myelodysplasia
Radiat
Downs etc

Question 3

Px

Answer 3

Marrow fail- anaemia, infec, bleeding, DIC.

Infilt- hepatosplenomegaly, gum hypertrophy, skin inv, CNS inv.

Question 4

Investig

Answer 4

WCC often high but can be anyth
Marrow biopsy req as blasts may not be prevalent in periph blood.
Microscopy
Cytogenic anal

Question 5

Complics

Answer 5

Infec
Septacaemia
Incr urate due to chemo
Leukostasis

Question 6

Mx

Answer 6

Chemo esp daunorubicin and cytarabine

Marrow transpl pluripotent HSCs with cyclosporina dn or methotrexate. Risk graft vs host, ifec, relpase and infert.