Acute Lymphoblastic Leukaemia Flashcards
1
Q
Defin
A
Malig of lymphoid cells affec B or T lines. Prevs maturat. Prolif immat blasts, marrow fail and tiss infilt.
Most comm CA of childhood, rare in ad.
CNS inv common.
2
Q
Cause
A
Genet suscep and env trigger eg rad dur preg, downs.
3
Q
Px
A
Marrow fail- anaemia, infec so low WC, bleed so low pl.
infilt- hepatosplenomegaly, lymphadenopathy, orhcidomegaly, CN palsy, meningism.
4
Q
Investig
A
Blood film
WCC us high
CXR and CT for lymphadenop
LP
5
Q
Mx
A
Tranfus Fluid Allopurinol to prev tum lysis synd Hickman line Immed IB AB for infec Prophylactic anti all Chemo eg vincristine, prednisolone, methotrexate, mercaptopurine.
