thrombolytics Flashcards
this binds + activates ATIII (which inactivates II, Xa)
- use for STEMI/NSTEMI + unstable angina)
A. Heparin, unfractionated
B. Dalteparin (Fragmin)
C. Enoxaparin (Lovenox)
D. Fondaparinux (Arixtra)
A. UF heparin (monitor PTT; causes osteoporosis)
LMWH used for cancers (less effective than UFH)
A. Heparin, unfractionated
B. Dalteparin (Fragmin)
C. Enoxaparin (Lovenox)
D. Fondaparinux (Arixtra)
B. Dalteparin/Fragmin (causes thrombocytopenia)
LMWH used for STEMI (less effective than UFH)
A. Heparin, unfractionated
B. Dalteparin (Fragmin)
C. Enoxaparin (Lovenox)
D. Fondaparinux (Arixtra)
C. Enoxoparin/Lovenox (causes TTP (~HIT), reverse with protamine)
synthetic polysacc that binds to ATIII active site; off label HIT use
A. Heparin, unfractionated
B. Dalteparin (Fragmin)
C. Enoxaparin (Lovenox)
D. Fondaparinux (Arixtra)
D. Fondaparinux/Arixtra (±cause fever; reverse w/ Andexanet)
FONdu is sugary sweet!
inh vitK carboxylation of F2,7,9,10 + ProtC/S; best for Afib + long term anticoag activity
warfarin (teratogen)
direct thrombin inh with a short half life that inactivates free and clot-Bound thrombin; use for PTCA/PIC
A. Bivalirudin (Angiomax)
B. Argatroban (Acova)
C. Dabigatran (Pradaxa)
A. Bivalirudin (Angiomax); short half life; monitor PTT
Reversibly binds to active site of thrombin; use for HIT
A. Bivalirudin (Angiomax)
B. Argatroban (Acova)
C. Dabigatran (Pradaxa)
B. Argatroban (Acova); monitor PTT
ARG! i HIT you
A for Active Site binding + Argatroban
give this thrombin-competitive inhibitor orally q24-36 hrs ; use for non valvular Afib+ VTE
A. Bivalirudin (Angiomax)
B. Argatroban (Acova)
C. Dabigatran (Pradaxa)
C. Dabigatran (Pradaxa)
reversible binds + inhitbits active site of Xa; causes major bleeding (2)
- Rivaroxaban (Xarelto) - causes major bleeding
2. Apixaban (Eliquis)
Recombinant tPA (tissue plasminogen activator); use for MI + acute stroke
Altepase
a less clot specific Mutant tPA with ↓ HL; ±cause arrythmia
Reteplase (Retavase) or Tenecteplase (TNKase)
Reteplase (Retavase)
Reteplase makes your heart Race!
a more clot specific Mutant tPA with ↑ HL
Reteplase (Retavase) or Tenecteplase (TNKase)
Tenecteplase (TNKase)
TENecteplase takes TENx longer!
Irreversibly inhibits thromboxane A2 formation + ↓ colorectal cancer
Aspirin (antiplatelet)
Weak oral PDE (plt) inhibitor
Dipyridamole (Persantine) or Cilostazol
Dipyridamole (Persantine)
oral PDE (plt) inhibitor used for Peripheral vascular disease
Dipyridamole (Persantine) or Cilostazol
Cilostazol
Cilo has Peripheral Vasc Dz
long term ADP (P2Y12) receptor inhibitor; Activated by CYP450; reversed by plt infusion
A. Clopidogrel (Plavix)
B. Prasugrel (Effient)
C. Ticagrelor (Brilinta)
A. Clopidogrel (Plavix); rarely causes TTP
CLopidogrel is CLingy for longterm relationships
C for CYP activator
irreversible ADP (P2Y12) receptor inhibitor
A. Clopidogrel (Plavix)
B. Prasugrel (Effient)
C. Ticagrelor (Brilinta)
D. Abciximab (Reopro)
B. Prasugrel (Effient); oral
and EFFIcient binder
reversible ADP (P2Y12) receptor inhibitor
A. Clopidogrel (Plavix)
B. Prasugrel (Effient)
C. Ticagrelor (Brilinta)
D. Abciximab (Reopro)
C. Ticagrelor (Brilinta); oral
Don’t panic Ticagrelor is Totally reversible
Monoclonal antibody against GP IIb/IIIa
A. Clopidogrel (Plavix)
B. Prasugrel (Effient)
C. Ticagrelor (Brilinta)
D. Abciximab (Reopro)
D. Abciximab (Reopro)
ximab = Ab
Fibrinogen analog; competes with endogenous fibrinogen that may cause Thrombocytopenia
Eptifibatide (Integrilin) or Tirofiban (Aggrastat)
Eptifibatide (Integrilin)
Eptifibatide is an Endo competitor
Fibrinogen analog used for NSTEMI; has an immediate effect
Eptifibatide (Integrilin) or Tirofiban (Aggrastat)
Tirofiban (Aggrastat)
Tirofiban is AGGressive and takes less Time
