Cancer Drugs Flashcards
1
Q
drug MOA: inh purine ring/nucleotide biosynth/interconversions; (2)
A
6-MP
6-TG
2
Q
drug MOA: inh DHF reduction; blocks TMP + purine synth
A
methotrexate
3
Q
drug MOA: block topoisomerase fx (5)
A
Camptothecins etoposide teniposide daunorubicine doxorubicin
4
Q
drug MOA: blocks cell activity (2)
A
protein tyrosine kinase inh’s
bortezomib Abs
5
Q
drug MOA: inh pyrimidine biosynth
A
PALA
6
Q
drug MOA: inh ribonucleotide reductase
A
hydroxyurea
7
Q
drug MOA: inh TMP synth
A
5-FU
8
Q
drug MOA: inh DNA synth (4)
A
Gemcitabine
Cytarabine
fludarabine
2-CL-oxyadenosine
9
Q
drug MOA: forms adducts w/DNA (6)
A
platinum analogs alkylating agents antitumor antibiotics mitomycin cisplatin temozolomide
10
Q
drug MOA: deaminates asparagine + inh prot synth
A
l-asparaginase
11
Q
drug MOA: inh fx of microtubules (5)
A
Paclitaxel vinca alkaloids colchicine estramustine taxanes
12
Q
side effects of cyclophosphamide (2)
A
hemorrhagic cystitis (dt to ↑acrolein) and SIADH
