Antiviral Drugs Flashcards
NRTI that can be used to prevent vertical tranZmission (from mother to baby)
Zidovudine (Retrovir)
NRTI’s that can be used to treat HIV and HBV; may also cause neutropenia** + pancreatitis (2)
- Lamivudine (Epivir)
2. Emtricitabine (Emtriva)
NRTI that can be used to treat HIV and HBV; may also cause nephroTox
Tenofovir (Viread) (alafenamide = prodrug)
NRTI that can be used to treat HIV and HBV; may also cause HS rxn
Abacavir (Ziagen)
HIV (Avir = AIDS); HS on my BACk
NNRTIs (direct inh) that cause vIvId dreams (4)
Efavirenz (Sustiva);
Nevirapine (Viramune);
Rilpivirine (Edurant);
Etravirine (Intelence)
HIV (Avir = AIDS)
HIV protease inh that cause Lipodystrophy syndrome (hyperglycemia, hyperlipidemia, fat distribution) (5)
Ritonavir (Norvir); Fosamprenavir (Lexiva); Atazanavir (Reyataz); Darunavir (Prezista); Lopinavir
HIV (Avir = AIDS)
What class of HIV drugs cause hyperglycemia, hyperlipidemia, fat distribution
protease inhibitors
HCV NS3/4A protease inhibitors that prevent maturation (5)
Grazoprevir; Simeprevir; Bocepravir; Telapravir, Paritaprevir
PREvirs = inh what protein?
HCV NS5A Inhibitor that prevents viral replication
Ledipasvir, daclatasvir, ombitasvir, elbasvir, velpatasvir
ASvir = inh what protein?
HIV entry inhibitors (2)
Enfuvirtide (Fuzeon) - injection rxn
Maraviroc (Selzentry)
Binds to HIV integrase to prevent viral DNA strand transfer (3)
Raltegravir;
Elvitegravir;
Dolutegravir
GRAvir = inh what protein?
HCV NS5B Polymerase Inhibitor that inh RNA pol and causes chain termination (2)
Sofosbuvir (Virunon;
Dasabuvir
BUvir = inh what protein?
HCV Nucleoside analog (~RNA) Thought to compete with viral nucleotides and cause chain termination
Ribavirin (~ribonucleoside); teratogenic**
HCV therapy that stimulates genes to establish antiviral state within cells
Interferons (flu sx + cytopenias)
Oseltamivir (Tamiflu) and Zanamivir (Relenza) prevent viral release and inc recovery from Influenza by inhibiting what protein?
Neuraminidase (NA)
