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Hematology > Thrombocytopenia > Flashcards

Thrombocytopenia Flashcards

1
Q

of platelets

A

less than 50,000

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2
Q

Nonimmunologic

A

Severe hemorrhage
Consumption
DIC

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3
Q

Immunologic

A

Autoimmune
ITP
TTP

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4
Q

Idiopathic Thrombocytopenia Purpura

A

Quantitative Disorder; characterized by the destruction of antibody-coated platelet in the spleen; shows through blotches on the skin

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5
Q

ITP Treatment

A

Steroids

Splenectomy

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6
Q

Thrombotic Thrombocytopenia Purpura

A

vWF is released from damaged endothelial; causes a bunch of thrombi laid down throughout the body

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7
Q

TTP Clinical Manifestations

A

Thrombocytopenia, HA, Fever, Neurologic complications, Renal Complications

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8
Q

TTP Treatment

A

Plasmapheresis

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9
Q

Nonimmunologic

A

Severe hemorrhage
Consumption
DIC

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10
Q

Immunologic

A

Autoimmune
ITP
TTP

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11
Q

Idiopathic Thrombocytopenia Purpura

A

Quantitative Disorder; characterized by the destruction of antibody-coated platelet in the spleen; shows through blotches on the skin

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12
Q

ITP Treatment

A

Steroids

Splenectomy

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13
Q

Thrombotic Thrombocytopenia Purpura

A

vWF is released from damaged endothelial; causes a bunch of thrombi laid down throughout the body; -ADAMS13 allows for the accumulation of the clot (mellaprotease deficiency)

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14
Q

TTP Clinical Manifestations

A

Thrombocytopenia, HA, Fever, Neurologic complications, Renal Complications

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15
Q

TTP Treatment

A

Plasmapheresis

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16
Q

Glanzmann’s thrombasthenia

A

Qualitative; 2b/3a defect

17
Q

Glazmann’s thrombasthenia Clinical Manifestations

A

minor bruising to severe bleeding; mucosal

18
Q

Glazmann’s Lab

A

only normal ristocetin aggregation; flow cytometry - CD41/CD61

19
Q

Bernard-Soulier

A

Qualitative; 1b/9 defect

20
Q

Bernard-Soulier Clinical Manifestations

A

gingival bleeding to GI bleeding

21
Q

Bernard-Soulier Lab

A

flow cytometry - CD42b/CD42a; abnormal aggregation with ristocetin

Hematology (11 decks)

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