Factors

Question 1

Factor 1

Answer 1

Fibrinogen

Question 2

Factor 2

Answer 2

Prothrombin

Question 3

Factor 3

Answer 3

Tissue Factor

Question 4

Factor 4

Answer 4

Calcium

Question 5

Factor 5

Answer 5

Labile Factor

Question 6

Factor 7

Answer 6

Stabile Factor

Question 7

Factor 8

Answer 7

Antihemophilia A

Question 8

Factor 9

Answer 8

Antihemophilia B - Christmas Factor

Question 9

Factor 10

Answer 9

Stuart Factor

Question 10

Factor 11

Answer 10

Plasma thromboplastin

Question 11

Factor 12

Answer 11

Hagemen Factor

Question 12

Factor 13

Answer 12

Fibrin Stabilizing Factor

Question 13

Vitamin K dependent Factors

Answer 13

2,7,9,10

Question 14

Bone Factors

Answer 14

4

Question 15

Endothelial Cell factors

Answer 15

3, 8(vWF),

Question 16

Intrinsic Pathway

Answer 16

12 -> 11 -> 9 -> 8 ->
9, 8, calcium and PF3 form a complex
start of the common pathway

Question 17

Common Pathway

Answer 17

10 -> 5 ->
10, 5, PF3, and calcium form a complex
2 -> 1 and 13 -> clot

Question 18

Extrinsic Pathway

Answer 18

3 -> 7
3, 7, and calcium form a complex
common pathway

Question 19

Prothrombin Time (PT)

Answer 19

give information about the extrinsic pathway; only plasma is used; sodium citrate used; .2 tissue thromboplastin - > .1 plasma; 10-13 secs for clot to form; affected by Warfarin (Coumadin); reported in INR

Question 20

Coumadin

Answer 20

interferes with the carboxylation of Vit K dependent factors to prevent the forming of a clot; therapeutic when the activity level of factor 2 is less than 50%

Question 21

INR equation

Answer 21

(patient’s PT in seconds/mean PT in secs for healthy normal) ^ISI

Question 22

aPTT

Answer 22

.1ml reagent -> .1ml plasma -> .1 ml CaCl2 -> clot

gives information for the intrinsic pathway; monitors Heparin

Question 23

Inhibitors of Coagulation

Answer 23

Anitthrombin

Protein C

Question 24

Antithrombin

Answer 24

inhibits thrombin, factor 12, 11, 10, 9

Question 25

Protein C

Answer 25

has cofactor protein S; inhibits factor 5 and 8; VIT K DEPENDENT

Question 26

Heparin

Answer 26

extracted from bovine lungs or porcine intestines; increases the activity of antithrombin; can be reversed through protamine sulfate

Question 27

LMWH

Answer 27

administered subcutaneous; catalyzes the neutralization of factor X; not measured with aPTT

Question 28

Fibrinogen Structure

Answer 28

Center E domain with 2 side D domains; contains Alpha, Beta , Gamma chains

Question 29

Formation of a clot

Answer 29

• Thrombin takes fibrinogen and removes the a and b chains – becomes fibrin
• binds to another fibrin molecule through H bonds
• Factor 13 is activated to cause covalent bond linkage between the D-domains
• fibrin clot is formed

Question 30

Fibrinolysis process

Answer 30

Plasminogen is changed to plasmin by T-Pa; plasmin is bound by antiplasmin

Question 31

vWF structure

Answer 31

contains 1b/9 site for platelet binding; has collagen binding site for the site of cut

Question 32

Thrombin Time

Answer 32

time for thrombin to convert fibrinogen to fibrin; reflects the fibrinogen concentration