RBCs Flashcards
Maturation Series
Rurbriblast Prorubricyte Rubricyte Metarubricyte Reticulocyte or Polychromat Mature RBC
Rubriblast
open chromatin
No hemoglobin synthesis
ALA synthesis
Prorubricyte
Begin of Hb synthesis
Rubricyte
Peak of Hb synthesis
Metarubricyte
All Hb synthesis
Nucleus degenerate mass(pyknotic)
Polychromat
Wright Stain
Retic
New Methylene Blue
RBC Maturation
72 hours to retic which circulates for about 2 days and then mature
RBC Metabolism
EM pathway
HM shunt
RL pathway
EM pathway
glucose to lactate; 90%; makes ATP
ATP in RBCs
Flexibility
Biconcave shape
Sodium-potassium pump
– sodium on outside
Erythropoeitin
hormone produce by kidneys to remedy low oxygen
Lipemia
lipids on RBCs that cause a falsely high hemoglobin
Reticuloendothelial system
site of RBC catabolism; 90% extravascular
Blood Vessel
site of 10% of RBC breakdown; broken to a dimer and transported with haptoglobin to the RES
Sites for Bone Marrow Aspiration
iliac crest
sternum
Active Bone Marrow
Spleen Sternum Skull Ribs Bones
ESR
the distance cells fall after being mixed with anti-coag and placed in tube
Factors Affecting ESR
Rouleux or agglutination, increased fibrinogen, temperature