things that increase/decrease MAC

Question 1

MAC definition

Answer 1

the partial pressure of an inhalation anesthetic at 1 atmosphere that prevents skeletal muscle movement in response to surgical skin incision in 50% of the population

Question 2

The lower the MAC, the more ___ the agent, and the ___ the blood:gas partition coefficient

Answer 2

potent, higher

Question 3

hypoxia

Answer 3

decrease

Question 4

infants

Answer 4

increase

Question 5

MAC usually greatest in

Answer 5

newborn

Question 6

anemia

Answer 6

decrease

Question 7

hyperthermia

Answer 7

increase

Question 8

lithium

Answer 8

decrease

Question 9

chronic alcohol and drug use

Answer 9

increase

Question 10

sedatives

Answer 10

decrease

Question 11

red heads

Answer 11

increase

Question 12

pregnancy

Answer 12

decrease

Question 13

hypothermia

Answer 13

decrease

Question 14

hypotension

Answer 14

decrease

Question 15

hyperthermia if >42C

Answer 15

decrease

Question 16

decreased PAO2

Answer 16

decrease

Question 17

hematocrit <10%

Answer 17

decrease

Question 18

decreased MAP

Answer 18

decrease

Question 19

PAO2 >95mmHG

Answer 19

decreased caused by

Question 20

elderly

Answer 20

decrease

Question 21

thyroid

Answer 21

no change

Question 22

CCB’s

Answer 22

decrease

Question 23

acute ETOH ingestion

Answer 23

decrease

Question 24

hypercalcemia

Answer 24

decrease

Question 25

decreased CBF

Answer 25

decrease

Question 26

decreased CMRO2

Answer 26

decrease

Question 27

hypernatremia

Answer 27

increase

Question 28

hyponatremia

Answer 28

decrease

Question 29

local anesthetics

Answer 29

decrease

Question 30

cocaine as a local anesthetic

Answer 30

increase

Question 31

sympathomimetic drugs (cocaine,ephedrine, amphetamine)

Answer 31

increase

Question 32

chronic amphetamine

Answer 32

decrease

Question 33

levodopa

Answer 33

increase (apex)

Question 34

lidocaine

Answer 34

decrease (apex)

Question 35

alpha 2 agonists

Answer 35

decrease(apex)

Question 36

cardiopulmonary bypass

Answer 36

decrease(apex)

Question 37

hypo-osmolarity

Answer 37

decrease (apex)

Question 38

metabolic acidosis

Answer 38

decrease (apex)

Question 39

hyperkalemia

Answer 39

does not affect! (apex)

Question 40

hypokalemia

Answer 40

does not affect! (apex)

Question 41

hypermagnesemia

Answer 41

does not affect! (apex)

Question 42

hypomagnesemia

Answer 42

does not affect! (apex)

Question 43

hypertension

Answer 43

does not affect! (apex)