IV induction agents

Question 1

acethylcholine is primarily para or sym?

Answer 1

para, but can kick start the SNS..

Question 2

GABA effect is primarily

Answer 2

inhibitory

Question 3

Gaba has _ units with _ subtypes

Answer 3

5, 3

Question 4

____ is a precursor to GABA

Answer 4

glutamate

Question 5

glutamate is an ___ neurotransmitter

Answer 5

excitatory

Question 6

chemoreceptors

Answer 6

pick up chemicals within the blood. like CO2. if you blunt the response, you wont know to breathe more when you have increased CO2

Question 7

IV induction agents are all hydrophillic or lipophiic?

Answer 7

lipophilic

Question 8

barbs type of drug

Answer 8

sedative, hypnotic, anticonvulsant

Question 9

barbs are derived from barbituric acid, which has effects that occur though ____ on ____ sites

Answer 9

substitutions on n1 c2 and c5

Question 10

which two barbs occur via substitution of C2

Answer 10

thiopental and methohexital

Question 11

thiopental and methohexital have a ___ onset and ___ duratoin

Answer 11

rapid and short

Question 12

which barb has myoclonic/excitatory movements with induction bolus?

Answer 12

methohexital

Question 13

pharmacokinetics of barbs - mechanism of action

Answer 13

post synaptic enhancement of GABA mediated inhibitor neurotransmitters and GABA mimetic effects

Question 14

protein binding of barbs

Answer 14

reversibly bound to plasma proteins

Question 15

when the unbound fraction of barbiturate is ____, the observed clinical effect is ____

Answer 15

greater

Question 16

barb absorption and distribution follow a __ compartment model

Answer 16

3

Question 17

how are the analgesic effects of barbs?

Answer 17

NONE. not useful for maintenance.

Question 18

barb CV system effects

Answer 18

mass depression.

Question 19

barbs do what do baroreceptor reflex

Answer 19

blunt it - a compensatory increase in HR may make this decrease in BP transient

Question 20

barbs resp effects

Answer 20

depress. decreases min vent, reduced tidal volume and resp rate, laryngospasm, bronchospasm

Question 21

barbs cause a dose dependent realize of

Answer 21

histamine

Question 22

absolute contraindication to barb use

Answer 22

allergic reaction, hx of acute intermittent porphyria or variegate