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pharm1 S.Horvath > etmoidate and precedex > Flashcards

etmoidate and precedex Flashcards

1
Q

etomidate analgesia

A

no intrinsic properties

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2
Q

etomidate structure

A

imidazole ring -open (stable) in solution, closed in body

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3
Q

etomidate PONV?

A

increases

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4
Q

etomidate special consideration

A

transient depression of adrenocortical function

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5
Q

transient depression of adrenocortical function puts what kind of people in danger

A

septic, hemorrhage, people with depressed cortisol function already

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6
Q

etomidate mechanism of action

A

gaba - potentiation

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7
Q

etomidate CV

A

CV STABLE!

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8
Q

etomidate duration

A

extremely short 3-5min

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9
Q

etomidate effect on sz

A

none. good for ECT

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10
Q

precedex mechanism of action

A

highly selective a2 adrenergic agonist

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11
Q

how does alpha 2 work

A

negative feedback loop

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12
Q

precedex CNS

A

decreases MAC requirement and decreases anesthetic requirement for opiod

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13
Q

precedex resp

A

safer

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14
Q

precedex has a high potential for

A

tolerance/ withdrawal

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15
Q

precedex contraindicated after

A

24h

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16
Q

precedex effect on ventilatory response to CO2

A

none - doesnt blunt chemoreceptors

17
Q

the release of glucocorticoids is triggered by

A

hypothalamus and pituitary

18
Q

does etomidate release histamine

A

no

19
Q

etomidate CNS

A

decreased CBF, CMRO2, ICP, IOP

20
Q

etomidate resp

A

suppress MV and increase RR, dec response to CO2

21
Q

metabolite of etomidate

A

inactive

22
Q

precedex considerations for women and children

A

cognitive effects - single exposure association w grades and IQ. 3rd trimester, 3 years old

23
Q

analgesia for precedex originates at

A

level of spinal cord

24
Q

what shouldn’t you give someone who’s in withdrawl from precedex

A

beta blockers . it will block beta but not alpha. severe peripheral vacosonstriction

25
Q

how does precedex effect chemorecptors

A

it doesnt

26
Q

does precedex effect ICP or CMRO2

A

no

27
Q

precedex can have safe resp but it can be

A

synergistic

28
Q

precedex cardiac

A

bradycardia, decreased SVR. bolus causes brief increase in SBP and bradycardia

pharm1 S.Horvath (18 decks)

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