barbs

Question 1

gaba is inhibitory or excitatory

Answer 1

inhibitory

Question 2

glutamate is inhibitory or excitatory

Answer 2

excitatory

Question 3

class of precedex

Answer 3

alpha 2 receptor agonist

Question 4

what does it mean if a drug is an agonist of GABA

Answer 4

binds to gaba receptor and inhibits the normal flow of electricity through the neuron

Question 5

what do NMDA antagonists do

Answer 5

block receptor sites of NMDA to slow down propagation of action potential. stops fight or flight hormones. and therefore promote sedation.

Question 6

which receptor has a negative feedback loop

Answer 6

alpha 2``

Question 7

IV induction agents are hydro or lipo?

Answer 7

lipophillic

Question 8

compartment 1

Answer 8

IV to central blood volume. assumed it is rapidly mixed and homogenous

Question 9

compartment 2

Answer 9

IV to vessel rich group of organs - brain, liver, kidneys, gut

Question 10

compartment 3

Answer 10

redistribution to fat

Question 11

barbs relationship to CYP?

Answer 11

barbs are CYP450 inducer

Question 12

benzo relationship to CYP

Answer 12

CYP substrate

Question 13

do barbs or benzos reduce CNS o2 and blood flow more

Answer 13

barbs

Question 14

benzo structure

Answer 14

imidazole ring.

Question 15

imidazole ring

Answer 15

open in solution, closed in body bc of ph changes. ph>4 becomes lipophilic! explains rapid onset.