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Volume Regulation (Diuretics) > Thiazide Diuretics > Flashcards

Thiazide Diuretics Flashcards

1
Q

Hydrochlorothiazide
MOA

A

inhibit Na+/Cl- uniporters in the apical membrane of the distal tubule and thus inhibit water reabsorption

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2
Q

Hydrochlorothiazide
Abs/Distrb/Elim

A

take about 1-3 weeks for stable reduction in blood pressure.
Half life 4hrs

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3
Q

Hydrochlorothiazide
Clinical use

A

Hypertension
Mild heart failure
Oedema
Nephrotic syndrome

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4
Q

Hydrochlorothiazide
Adverse effects

A

Potassium depletion
Hyperglycemia
Hypercalcemia
Gout
Erectile dysfunction
Hypersensitivity

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Volume Regulation (Diuretics) (6 decks)

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