Loop Diuretics Flashcards
1
Q
Furosemide
MOA
A
Loop diuretics act to inhibit the NKCC channels in the apical membrane of the thick ascending limb of the loop of Henle, inhibiting Na and Cl reabsorption, results in the reduction of water reabsorption in the collecting ducts
2
Q
Furosemide
Abs/Distrb/Elim
A
Orally effects peak 1 hour after administration
Intravenously effects peak 30 minutes
Duration of action 4 to 6 hours.
3
Q
Furosemide
Clinical Use
A
Acute pulmonary oedema
Congestive heart failure
Hypertension
Ascites due to liver cirrhosis
Hypercalcemia
Hyperkalaemia
4
Q
Furosemide
Adverse effects
A
Hypokalaemia
Hypocalcaemia
Hypovolemia
Gout
Hypotension
Ototoxicity
