Carbonic Anhydrase Inhibitors

Question 1

Acetazolamide
MOA

Answer 1

reversibly inhibits the enzyme carbonic anhydrase, leads to reduced Na+ an bicarb exchange causes increased delivery of Na+ and bicarb to distal part of nephron for excretion.

Question 2

Acetazolamide
Abs/Distrb/Elim

Answer 2

Oral
Several day therapy
- weak effect due to being overpowered by reabsorption of Na+ downstream (loop of Henle)

Question 3

Acetazolamide
Clinical use

Answer 3

Glaucoma
reduces intraocular pressure by reducing formation of aqueous humour

Question 4

Acetazolamide
Adverse effects

Answer 4

Metabolic acidosis