Thiazide Diurectics

Question 1

What does it treat?

Answer 1

HTN, HF, Liver and Kidney Failure

Question 2

What is the common drug?

Answer 2

Hydrochlorothiazide (HCTZ)

Question 3

What part of the tubule does it work on?

Answer 3

Proximal portion of Distal Convoluted Tubules

Question 4

What does it prevent form reabsorbing?

Answer 4

Na and Cl

Question 5

What does blocking reabsorption cause?

Answer 5

Excretion of Na, H20, K, Cl; ↑ Urine Output

Question 6

What needs to work well so medication can have full effect?

Answer 6

Kidney perfusion and GFR

Question 7

Common S/E?

Answer 7

FE Imbalances: HypoNA, HypoCl, FVD, HypoK; Hyperglycemia, Hyperuricemia,

Question 8

What to monitor?

Answer 8

FE levels, Blood Glucose, Uric Acid

Question 9

Common dose/route?

Answer 9

PO (capsules and tablets)

Question 10

Can you give it with food and what is the best time to give?

Answer 10

Yes, last dose should be before 3PM, NO BEDTIME

Question 11

What drugs to watch out for when giving medication?

Answer 11

Lithium, Digoxin, Steroids, Cholestyramine