ACE Inhibitors

Question 1

What is the common root name?

Answer 1

-pril

Question 2

What are common drugs?

Answer 2

Captopril, Enalapril, Lisinopril

Question 3

How does it work?

Answer 3

Blocks Angiotensin II (A2) production

Question 4

What does blocking A2 cause? (3)

Answer 4

Vasodilation, urinary excretion of Na & H2O and retain K

Question 5

Side Effects? (7) (HHypoMANDR)

Answer 5

HypoTN, rash, metallic taste, hyperkalemia, neutropenia, dry cough, angioedema

Question 6

What is another name for ACE?

Answer 6

Kinase II (K2)

Question 7

What do ACE/K2 cause? Why?

Answer 7

↑ in Bradykinin ; no ACE/K2 to break it down

Question 8

↑ in Bradykinin causes what 2 S/S?

Answer 8

Dry cough and/or Angioedema

Question 9

1st dose of ACE Inhibitor given at?

Answer 9

Low dose and gradual ↑ (prevent HypoTN)

Question 10

What is monitored?

Answer 10

BP (HypoTN), S/E: IV Epi, Stop Med(A); CBC w/Diff (N); Other Meds & Food (Hk↑)

Question 11

How is it usually given?

Answer 11

PO only; 2-3x Daily (HTN); 3x for Daily (CHF)

Question 12

Can you give it with food?

Answer 12

Yes, except for Captopril (1HR before meal)

Question 13

What are the therapeutic uses? (3)

Answer 13

HTN, HF, Nepropathy

Question 14

Is it safe for pregnant/lactating women?

Answer 14

No, Category D medication