Thermoregulatoin Flashcards

1
Q

By what modes is heat gained and lost?

A

Heat is gained by internal production, convection, conduction and radiation

Its lost by evaporation, convection, conduction and radiation

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2
Q

How does convection work?

A

Known as “Fluid” conduction aka wind chill or water chill

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3
Q

How does the body detect temperature?

A

It has cold and warmth receptors

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4
Q

How do cold/warmth receptors work?

A

Cold receptors decrease firing rate when heated and increase when cooled. (Dynamic response)
They peak at 30*

Warmth receptors increase firing rate wehn heated and decrease when cooled (dynamic response). They peak at ~40*

They’re firing rate overlaps at 37*

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5
Q

Where are temp receptors found?

A
  • Peripheral Thermoreceptors in skin (mainly face/scrotum) detect environmental temp.
  • Central Thermoreceptors in spinal cord, abdo organs and hypothalamus detect core temp.
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6
Q

Where are temperature signals integrated and managed?

A

The hypothalamus

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7
Q

How does our body increase heat production in response to cold stress?

A

Increases heat production:

  • Voluntary muscle activity
  • Involuntary muscle activity (Shivering)
  • Increasing metabolic rate
  • Non-shivering thermogenesis (Brown adipose in babies)
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8
Q

How do our bodies decrease heat loss in cold stress?

A
  • Symp. Arteriolar Vasoconstriction

- Behavioural Response (clothes, warm places & reduce surface area)

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9
Q

Define hypothermia?

A

A core body temp <35*

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10
Q

How does frostbite occur?

A

2 mechanisms of action:
Vascular:
- Vasoconstriction & thombi due to increased blood viscosity lead to anoxia

Cellular:

  • Ice crystals form in ECF, increases osmolarity and pulling water out of cells
  • Cellular dehydration leads to death
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11
Q

How do cold periods inflict risk of death?

A

People often get MIs and strokes following cold periods.

Thrombi, viscous blood and vasoconstriction all stress the heart and risk MIs & Stroke

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12
Q

How does the body decrease heat production in response to heat stress?

A

Decrease physical activity and food intake

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13
Q

How does the body raise heat loss in response to heat stress?

A
  • Peripheral vasodilation
  • Sweating
  • Behaviroural changes (sprawling to raise surface area, removing clothes, shade)
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14
Q

Define heat exhaustion?

A

When core Temp reaches 37.5-40*
A disturbed fluid/salt balance due to sweatin causes vasodilation and so a drop in central blood volume

You get headahce,s confusion, nausea, clammy skin, hypotension, tachycardia, fainting

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15
Q

Define heat stroke?

A

When temp gets over 40* the temp control mechanisms fail.

You stop sweating and go into circulatory collapse

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16
Q

What causes a fever?

A

Endogenous pyrogens (E.g. IL-1 & IL-6)

They cause prostaglandin production by cyclo-oxygenase in the hypothalamus which raises the “set-point” (thermostat) in the hypothalamus.

17
Q

Why do aspirin and paracetamol break fevers?

A

They inhibit cyclo-oxygenase.

Originally to prevent sensitizes bradykinin in nociceptors but also prevents raising the set point of the hypothalamus