Blood Flashcards
Average circulating volume of blood?
5L
How much blood circulates where?
1L in the lungs
1L in the heart/arterial circulation
3L in the venous circulation
Main 6 functions of blood?
- Carrying compounds
- Clotting
- O2/CO2 carriage
- Defence
- Thermoregulation
- Maintaining ECF pH
What kind of compounds does blood cary?
- Hormones
- Enzymes
- Nutrients
How much of plsama is water?
~95%
What are the 3 groups of plasma proteins?
- Albumin
- Globulins
- Clottin factors
What does albumin do?
- Binds to drugs
- Transports lipids/steroid hormones
- Adds to coloid oncotic pressure
What are the main types of globulins int he blood?
alpha/beta
gamma
What do alpha/beta globulins in blood do?
Transport Lipids & vitamins
What do gamma globulins in blood do?
Theyre antibodies
What is oncotic pressure?
The osmotic pressure produced by uneven concs of plasma proteins.
Pulls water from the ISF to the plasma
Whats the most abundent blood cell?
Red Blood Cell
Life span of an RBC?
120 days
tructure of a RBC?
- Non-nucleated
- Bi-concave
- Highly flexible
What protein controls erythropeiosis?
Erythropoietin
Where is erythropoietin made?
The kidneys & liver
When would eryhtropioetin secretion be increased?
When Oxygen supply to kidneys is reduced.
E.g. anaemia, hypoxia, haemorrhage, lung disease
Name the 5 main white blood cells?
Neutrophils Eosinophils Basophils Monocytes Lymphocytes
Which is the most common WBC?
Neutrophils
Whats the half-life of neutrophils?
Around 6 hours
What do neutrophils do?
Phagocytose in bacterial infection.
Heavy involvement in acute inflammation
What do eosinophils do?
Attack pathogens too large for other leukocytes
E.g. Parasites
When do eosinophils rapidly increasE?
Allergyic reactions
Type 1 hypersensitivitY
What do basophils do?
Release histamine/heparin to promote inflammation
