Thermo in context Flashcards
1
Q
How are Ka and Kd related in drug-ligand interactions?
A
Kd = 1/Ka
2
Q
Effective drugs have large positive/negative values of ΔG, high/low values for Ka, but very small/large values for Kd
A
negative
high
small
3
Q
What is the inhibition constant?
A
Ki
4
Q
How does the IC50 to measure inhibitor potency?
A
The inhibitor conc that reduces enzymatic activity to 50% in the presence of substrate
5
Q
What is the viracept?
A
HIV-1 protease inhibitor
6
Q
In H bonding angular dependence produces _________ in binding
A
directionality
7
Q
Entropy and hydrophobic effect: change in solvent _______ ______ ____ is a key determinant of hydrophobic strength
A
accessible surface area
8
Q
List common non-covalent interactions
A
- salt bridging
- H bonding
- VdW
- aromatic stacking
- hydrophobic effect
